基本信息
views: 4
Career Trajectory
Bio
The major goal of our laboratory is to elucidate the molecular and cellular mechanisms underlying the clinical anticonvulsant effects of the ketogenic diet (KD), an effective non-pharmacological treatment for medically refractory epilepsy. We are also attempting to validate the neuroprotective (and potentially) disease-modifying effects of the KD. Recent published studies have focused on the antioxidant properties of ketone bodies – which are produced during KD treatment – and fatty acids (particularly, polyunsaturated fatty acids). The laboratory utilizes cellular in vitro electrophysiological techniques (i.e., single-channel and whole-cell patch-clamp, and IR-DIC slice recordings), combined with molecular genetic approaches, behavioral assessments (e.g., continuous video-EEG monitoring, high-density multi-electrode recordings of brain slices), and cellular fluorescence imaging. The principal animal model of epilepsy studied in our laboratory is the epileptic Kcna1-null mouse, which develops spontaneous recurrent seizures early in post-natal development.
Research Interests
Papers共 272 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
CRC Press eBookspp.107-111, (2023)
Cited0Views0Bibtex
0
0
Seizure (2023): 42-57
Neuropharmacology (2023): 109513-109513
biorxiv(2023)
CRC Press eBooks (2023)
NEUROPHARMACOLOGY (2023)
NEUROLOGYno. 17 (2023)
Load More
Author Statistics
#Papers: 273
#Citation: 10860
H-Index: 55
G-Index: 99
Sociability: 7
Diversity: 0
Activity: 2
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn