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T cells are a major effector arm of the adaptive immune system. We study two fascinating properties of T cells: they are highly motile cells able to migrate all around the body, and each T cell is subtly different. Both the continuous motion and the diversity of a T cell population are critical to mounting effective T cell responses. We investigate how T cells move through complex tissue, through what mechanisms T cell collectives avoid crowding issues, and how the interactions made during migration impact T cell heterogeneity. We take a systems approach to study T cell immunity at the organism level (responses to infection, homeostasis), at the tissue level (T cell trafficking, localization, adaptation to distinct tissue environments), at the cell level (migration, navigation strategies through tissue-imposed obstacles), and at the within cell level (cytoskeletal processes, gene expression and T cell receptor sequences), illustrated in Figure.
T cells are a major effector arm of the adaptive immune system. We study two fascinating properties of T cells: they are highly motile cells able to migrate all around the body, and each T cell is subtly different. Both the continuous motion and the diversity of a T cell population are critical to mounting effective T cell responses. We investigate how T cells move through complex tissue, through what mechanisms T cell collectives avoid crowding issues, and how the interactions made during migration impact T cell heterogeneity. We take a systems approach to study T cell immunity at the organism level (responses to infection, homeostasis), at the tissue level (T cell trafficking, localization, adaptation to distinct tissue environments), at the cell level (migration, navigation strategies through tissue-imposed obstacles), and at the within cell level (cytoskeletal processes, gene expression and T cell receptor sequences), illustrated in Figure.
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论文共 44 篇作者统计合作学者相似作者
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Vincent M. Luo,Connie Shen,Samantha Worme, Aanya Bhagrath,Estelle Simo-Cheyou,Steven Findlay,Steven Hebert,William Wai Lam Poon, Zahra Aryanpour, Thomas Zhang,Rene P. Zahedi,Jonathan Boulais,
Hassan Jamaleddine,Dakota Rogers, Genevieve Perreault, Jeremy Postat,Dhanesh Patel,Judith N. Mandl,Anmar Khadra
Vincent M. Luo,Connie Shen,Samantha Worme, Aanya Bhagrath,Estelle Simo-Cheyou,Steven Findlay,Steven Hebert,William Wai Lam Poon, Zahra Aryanpour, Thomas Zhang,Rene P. Zahedi,Jonathan Boulais,
Molecular and cellular biologyno. 1 (2024): 1-16
Journal of cell scienceno. 11 (2023)
引用2浏览0WOS引用
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CELL SYSTEMSno. 12 (2023): 1059-1073.e5
Alexandre P Meli, Gabriel A Russell, Sharada Swaminathan,Laura Weichselbaum, Clara A MacMahon,Erwan Pernet,Danielle Karo-Atar,Dakota Rogers,Annie Rochette,Ghislaine Fontes,Judith N Mandl,Maziar Divangahi,
Mucosal immunologyno. 6 (2023): 801-816
The Journal of experimental medicineno. 8 (2023)
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