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Prof de Haan’s research focuses on improving the lives of diabetic patients by reducing the burden of cardiovascular complications. A focus has been on the pathogenesis of oxidant stress, where free radicals build up in the body and elicit damage, in particular, their contribution to diabetic macrovascular complications, such as diabetes-associated atherosclerosis and diabetes-linked endothelial dysfunction. This has led to significant discoveries on the role of endogenous antioxidant enzyme defences to limit disease. Her work has identified several key antioxidant enzyme mimetics, as well as activators of the transcriptional regulator of oxidant stress, Nrf2, as novel therapeutic strategies to lessen diabetic cardiovascular complications. Her research now focuses on the interplay between antioxidant defence and inflammation, with a particular focus on the Nrf2/NLRP3-inflammasome axis. Her preclinical investigations hold tremendous potential for translation into humans, and this next phase of her research is anticipated to yield far better cardiovascular outcomes than previous non-selective antioxidants such as vitamins C and E.
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Arpeeta Sharma, Judy Choi, Lachlan Sim, Abhiroop Dey,Muthukumar Mohan,Phillip Kantharidis,Lisa Dietz,Peter Sandner,Judy B. de Haan
FRONTIERS IN CARDIOVASCULAR MEDICINE (2023): 1220095-1220095
biorxiv(2022)
Redox biology (2020): 101803-101803
crossref(2018)
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