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How is a cell created from its molecular constituents? Individual proteins are typically only a few nanometers in size. Without a blueprint or an architect, these tiny molecular parts organize themselves in a dynamic and self-correcting manner to form precise cellular structures that may be four or five orders of magnitude larger. Understanding the proper spatial and temporal arrangement of macromolecules in cells, the large-scale coordination of their functions, and the choreography of their movements requires the discovery of organizational principles and mechanisms that work at a cellular scale, over the rapid time-frames consistent with life processes.
The research of our group explores the mechanics and dynamics of cell self-organization and movement in a variety of cells ranging from bacteria to fish skin cells. Our current work focuses on three areas: 1) the actin-based motility of intracellular bacterial pathogens such as Listeria monocytogenes, 2) the whole-cell crawling of epithelial cells and leukocytes, and related processes such as phagocytosis in macrophages, and 3) the dynamics of cellular organization in bacteria and diatoms. A strength of our work is its highly interdisciplinary nature, bridging cell biology, microbiology, and biophysics. By studying diverse questions in diverse biological systems, using both bottom-up approaches (biochemical reconstitution, single-molecule force measurements, mathematical modeling) and top-down approaches (genetic and pharmacological perturbations, quantitative video-based analysis of cell movement, shape, and mechanical coupling), we aim to develop a broad conceptual understanding of the organizational rules that give rise to large-scale cell structure and coordinated movement.
The research of our group explores the mechanics and dynamics of cell self-organization and movement in a variety of cells ranging from bacteria to fish skin cells. Our current work focuses on three areas: 1) the actin-based motility of intracellular bacterial pathogens such as Listeria monocytogenes, 2) the whole-cell crawling of epithelial cells and leukocytes, and related processes such as phagocytosis in macrophages, and 3) the dynamics of cellular organization in bacteria and diatoms. A strength of our work is its highly interdisciplinary nature, bridging cell biology, microbiology, and biophysics. By studying diverse questions in diverse biological systems, using both bottom-up approaches (biochemical reconstitution, single-molecule force measurements, mathematical modeling) and top-down approaches (genetic and pharmacological perturbations, quantitative video-based analysis of cell movement, shape, and mechanical coupling), we aim to develop a broad conceptual understanding of the organizational rules that give rise to large-scale cell structure and coordinated movement.
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论文共 307 篇作者统计合作学者相似作者
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Cellno. 2 (2024): 219-224
Julie A Theriot,Anne Simonsen,Iva Tolić, Manuel D Leonetti,Satyajit Mayor,Patricia Bassereau,Ewa K Paluch, Jiahuai Han,Markus W Covert,Noboru Mizushima, Samara Reck-Peterson, Andreas Strasser,
Cellno. 2 (2024): 219-224
bioRxiv : the preprint server for biology (2023)
BIOPHYSICAL JOURNALno. 3 (2023): 301A-301A
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Matheus P. Viana,Jianxu Chen,Theo A. Knijnenburg,Ritvik Vasan,Calysta Yan, Joy E. Arakaki,Matte Bailey,Ben Berry,Antoine Borensztejn,Eva M. Brown, Sara Carlson, Julie A. Cass,
Cytoskeleton (Hoboken, N.J.)no. 1-2 (2023): 34-51
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