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个人简介
In all organisms proteins are at the centre of most cellular processes. Proteins rarely act alone but form complexes of all sizes and properties. The function of each protein can only be understood as part of the complex. Currently, there is no general tool that makes these protein interactions accessible to our observation. High-resolution structures give this information and can be obtained as a result of intense work. However, few soluble protein complexes exhibit the requirements to be studied in this way. The large group of insoluble protein complexes is almost entirely excluded from structural investigations as a result of being located on solid structures like chromatin, membranes, and the cytoskeleton. I hypothesize that there is technology within our grasp, cross-linking, mass spectrometry and bioinformatics, that reveals the information about which proteins interact with each other and what parts of these proteins make contact. Together with my research team I develop this technology and would like to apply it to a large and insoluble protein complex that is beyond even the most daring dreams using current technologies.
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论文共 417 篇作者统计合作学者相似作者
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Ansgar Zoch, Gabriela Konieczny,Tania Auchynnikava,Birgit Stallmeyer,Nadja Rotte, Madeleine Heep, Rebecca V Berrens, Martina Schito,Yuka Kabayama, Theresa Schöpp,Sabine Kliesch,Brendan Houston,
Molecular cellno. 6 (2024): 1021-1035.e11
Nature structural & molecular biologypp.1-11, (2024)
Brinda Vallat,Benjamin M Webb,John D Westbrook,Thomas D Goddard,Christian A Hanke,Andrea Graziadei,Ezra Peisach,Arthur Zalevsky, Jared Sagendorf, Hongsuda Tangmunarunkit,Serban Voinea,Monica Sekharan,
Reshma Thamkachy,Bethan Medina-Pritchard,Sang Ho Park, Carla G. Chiodi,Juan Zou, Maria de la Torre-Barranco, Kazuma Shimanaka,Maria Alba Abad, Cristina Gallego Páramo, Regina Feederle, Emilija Ruksenaite,Patrick Heun,
crossref(2024)
Pragya Parashara,Bethan Medina-Pritchard,Maria Alba Abad, Paula Sotelo-Parrilla, Reshma Thamkachy, David Grundei,Juan Zou, Vimal Das, Zhaoyue Yan,David A Kelly,Toni McHugh,Juri Rappsilber,
biorxiv(2024)
Michael W Webster,Adrien Chauvier, Huma Rahil,Andrea Graziadei, Kristine Charles,Maria Takacs,Charlotte Saint-André,Juri Rappsilber,Nils G Walter,Albert Weixlbaumer
bioRxiv : the preprint server for biology (2024)
Belén Pacheco-Fiallos, Matthias K. Vorländer, Daria Riabov-Bassat, Laura Fin,Francis J. O’Reilly, Farja I. Ayala,Ulla Schellhaas,Juri Rappsilber,Clemens Plaschka
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