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The Adelman laboratory investigates the dynamic interplay between signals from the environment and transcription by RNA polymerase II (Pol II). The ability to rapidly integrate multiple extra- and intra-cellular cues to produce specific patterns of gene expression is essential for the growth, development, and survival of all organisms; however, the molecular mechanisms leading from these signals to the coordinated activation of gene networks are not well understood. The group uses genomic approaches in Drosophila and murine model systems to measure changes in Pol II distribution, gene expression, and epigenetic chromatin signatures that occur when a cell receives specific stimuli from the environment. The mechanisms underlying these changes are then probed using a combination of genetic and biochemical techniques.
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论文共 116 篇作者统计合作学者相似作者
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Emily G. Kaye, Kavyashree Basavaraju,Geoffrey M. Nelson,Helena D. Zomer,Debarun Roy, Irene Infancy Joseph, Reza Rajabi-Toustani,Huanyu Qiao,Karen Adelman,Prabhakara P. Reddi
Research square (2024)
Emily C. Wheeler,Benjamin J. E. Martin,William C. Doyle, Sofia Neaher, Caroline A. Conway, Caroline N. Pitton,Rebecca A. Gorelov,Melanie Donahue,Johann C. Jann,Omar Abdel-Wahab,Justin Taylor,Michael Seiler,
Benjamin J. E. Martin,Eileen F. Ablondi,Christine Goglia,Claudia A. Mimoso, Piero R. Espinel-Cabrera,Karen Adelman
Cellno. 24 (2023): 5290-+
Science translational medicineno. 714 (2023)
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Gongwei Wu,Noriaki Yoshida,Jihe Liu,Xiaoyang Zhang, Yuning Xiong,Tayla B. Heavican-Foral,Huiyun Liu,Geoffrey M. Nelson,Lu Yang, Renee Chen,Katherine A. Donovan, M. Jones,
Cancer Researchno. 7_Supplement (2023): 5755-5755
BLOOD (2023): 4142
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