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Description of Research Expertise
Improved therapeutic response via metabolic modulation.
Development of a safe and reproducible method to selectively acidify and deenergize the human cancers. Specifically, we seek to employ the natural tendency of cancers to convert glucose to lactate as a method for selective intracellular acidification, which is known to potentiate tumor response to chemotherapy, radiation therapy, hyperthermia, and photodynamic therapy. In vivo 31P and 1H MRS demonstrated that human cancer xenografts such as melanoma, breast, prostate, ovarian and glioma in immunosuppressed mice treated with metabolic modulators exhibit a sustained and tumor-selective decrease in pH, bioenergetics and increase in lactate and subsequent sensitization to chemo- and radiation therapy.
Expertise
Mouse xenograft development, tumor cells studies, drug delivery, metabolomics, and tumor micro-environment modulation.
Surface coil development to perform MRI/MRS studies on preclinical models.
1H, 31P, 13C MRS.
T1, T2, DTI, DCE MRI.
Measurement of test-retest reproducibility of SUV on PET in cancer patients.
Description of Research Expertise
Improved therapeutic response via metabolic modulation.
Development of a safe and reproducible method to selectively acidify and deenergize the human cancers. Specifically, we seek to employ the natural tendency of cancers to convert glucose to lactate as a method for selective intracellular acidification, which is known to potentiate tumor response to chemotherapy, radiation therapy, hyperthermia, and photodynamic therapy. In vivo 31P and 1H MRS demonstrated that human cancer xenografts such as melanoma, breast, prostate, ovarian and glioma in immunosuppressed mice treated with metabolic modulators exhibit a sustained and tumor-selective decrease in pH, bioenergetics and increase in lactate and subsequent sensitization to chemo- and radiation therapy.
Expertise
Mouse xenograft development, tumor cells studies, drug delivery, metabolomics, and tumor micro-environment modulation.
Surface coil development to perform MRI/MRS studies on preclinical models.
1H, 31P, 13C MRS.
T1, T2, DTI, DCE MRI.
Measurement of test-retest reproducibility of SUV on PET in cancer patients.
研究兴趣
论文共 76 篇作者统计合作学者相似作者
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Stepan Orlovskiy,Pradeep Kumar Gupta,Jeffrey Roman,Fernando Arias-Mendoza, David S. Nelson,Cameron J. Koch,Vivek Narayan,Mary E. Putt,Kavindra Nath
Pradeep Kumar Gupta, Stepan Orlovskiy,Fernando Arias-Mendoza,David S. Nelson, Aria Osborne,Stephen Pickup,Jerry D. Glickson,Kavindra Nath
CANCERSno. 2 (2024): 365
RSC Advancesno. 29 (2023): 19813-19816
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NMR IN BIOMEDICINEno. 4 (2023)
Narayan Datt Soni,Anshuman Swain,Paul Jacobs, Halvor Juul, Ryan Armbruster,Ravi Prakash Reddy Nanga,Kavindra Nath,Corinde Wiers,John Detre,Ravinder Reddy
Magnetic resonance in medicine (2023)
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RSC advancesno. 29 (2023): 19813-19816
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Narayan Datt Soni,Anshuman Swain, Paul Jacobs, Halvor Juul, Ryan Armbruster,Ravi Prakash Reddy Nanga,Kavindra Nath, Corinde Wiers,John Detre,Ravinder Reddy
MAGNETIC RESONANCE IN MEDICINEno. 1 (2023): 259-269
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Narayan Datt Soni,Anshuman Swain,Paul Jacobs, Halvor Juul, Ryan Armbruster, Ravi Prakash Reddy Nanga,Kavindra Nath,Corinde E. Wiers,John A. Detre,Ravinder Reddy
Magnetic Resonance in Medicineno. 1 (2023): 259-269
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