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Dr. Zhao also provided the first genome-wide description of nucleosome positioning in the mammalian genome, describing the location of nucleosomes relative to transcriptional start sites in CD4+ T cells and demonstrating extensive nucleosome reorganization in promoters and enhancers following T cell receptor signaling.
Using the tools he has pioneered, Dr. Zhao has built a schema of modifications associated with particular areas of the genome; now, he wants to understand how they are regulated and how regulatory mechanisms contribute to processes like cellular memory, differentiation, and pathology. His laboratory is studying how the interplay between transcription factors and various chromatin modifying enzymes, including both histone modifying enzymes and ATP-dependent chromatin remodeling complexes, regulates the dynamic epigenomic landscapes in various hematopoietic lineages. Dr. Zhao is also investigating how epigenome dynamics regulate memory and function during differentiation of induced pluripotent stem (iPS) cells and hematopoietic stem cells to various blood lineages.
Additionally, Dr. Zhao is looking beyond two-dimensional relationships in the genome that regulate gene expression. It is known that the position of a specific gene in the nucleus is important for its regulation and expression—for example, evidence in yeast suggests that genes located at the nuclear periphery are repressed. Dr. Zhao aims to understand the three-dimensional organization of the nucleus as it relates to gene expression.
He received the NIH Director’s Award in recognition of innovative contributions that have provided novel insights into epigenetic control of gene expression in 2011 and NIH Merit Awards in 2007 and 2008. Dr. Zhao also received an APAO Award for Significant Accomplishments in Biomedical Research in 2008 and was elected a Fellow of the American Association for the Advancement of Science in 2012. Dr. Zhao has authored or coauthored more than 100 papers and book chapters. He is on the editorial boards of Genome Research and Cell & Bioscience.
Using the tools he has pioneered, Dr. Zhao has built a schema of modifications associated with particular areas of the genome; now, he wants to understand how they are regulated and how regulatory mechanisms contribute to processes like cellular memory, differentiation, and pathology. His laboratory is studying how the interplay between transcription factors and various chromatin modifying enzymes, including both histone modifying enzymes and ATP-dependent chromatin remodeling complexes, regulates the dynamic epigenomic landscapes in various hematopoietic lineages. Dr. Zhao is also investigating how epigenome dynamics regulate memory and function during differentiation of induced pluripotent stem (iPS) cells and hematopoietic stem cells to various blood lineages.
Additionally, Dr. Zhao is looking beyond two-dimensional relationships in the genome that regulate gene expression. It is known that the position of a specific gene in the nucleus is important for its regulation and expression—for example, evidence in yeast suggests that genes located at the nuclear periphery are repressed. Dr. Zhao aims to understand the three-dimensional organization of the nucleus as it relates to gene expression.
He received the NIH Director’s Award in recognition of innovative contributions that have provided novel insights into epigenetic control of gene expression in 2011 and NIH Merit Awards in 2007 and 2008. Dr. Zhao also received an APAO Award for Significant Accomplishments in Biomedical Research in 2008 and was elected a Fellow of the American Association for the Advancement of Science in 2012. Dr. Zhao has authored or coauthored more than 100 papers and book chapters. He is on the editorial boards of Genome Research and Cell & Bioscience.
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Shuai Liu,Yaqiang Cao,Kairong Cui,Gang Ren, Tingting Zhao, Xuezheng Wang,Danping Wei,Zuojia Chen,Rama Krishna Gurram,Chengyu Liu,Chuan Wu,Jinfang Zhu,
Immunity (2024)
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Cell reportsno. 8 (2023): 112924-112924
crossref(2023)
Frontiers in immunology (2023): 1186580
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Chinmayi Chandrasekhara,Rajesh Ranjan, Jennifer A Urban,Brendon E M Davis,Wai Lim Ku,Jonathan Snedeker,Keji Zhao,Xin Chen
PLoS biologyno. 5 (2023): e3002098-e3002098
Immunityno. 8 (2022): 1402-1413.e4
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