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The Margulies Lab examines mechanisms of myocardial remodeling to identify targets for therapeutic interventions. Many of our inquiries are initiated by multilevel examinations of explanted human heart tissues obtained at the time of transplantation or organ donation to permit insights into both the heterogeneity of myocardial adaptations to disease and identification of dominant mechanisms and responses. The Margulies lab has a longstanding focus on load-dependent myocardial remodeling with current studies focusing on mechanisms of load-dependent maturation, mechanical memory and pathological myocardial hypertrophy. In addition, the lab is actively engaged in studies examining regulation of contractility by microtubules and other cytoskeletal elements, cardiotoxicity associated with VEGF-anti-angiogenic tyrosine kinase inhibitors, disease-associated shifts in cardiac metabolism, mechanisms of inherited cardiomyopathies, advanced myocardial phenotyping using digital pathology and machine learning techniques, and integrated genomic inquiries designed to identify molecular mechanisms of myocardial pathology. Increasingly, complementary use of primary human cardiac myocytes, iPSC-derived cardiac myocytes and engineered cardiac microtissues are employed as versatile tools to balance human relevance and mechanistic clarity to advance these inquiries. Our work also includes, strategic patient-based proof-of-concept studies.
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Journal of Clinical and Translational Scienceno. s1 (2024): 3-3
CIRCULATION-HEART FAILUREno. 2 (2024): e010950-e010950
Senthil Selvaraj, Shachi Patel,Andrew Sauer,Robert McGarrah,Philip Jones, Lydia Kwee,Sheryl L. Windsor,Olga Ilkayeva,Michael Muehlbauer, Christopher B. Newgard,Barry Borlaug,Dalane W. Kitzman,
Journal of the American College of Cardiologyno. 13 (2024): 317
Basic Research in Cardiologypp.1-13, (2024)
JACC-BASIC TO TRANSLATIONAL SCIENCEno. 1 (2024): 1-15
Joycie Chang,Ali Javaheri,Andrew Sauer,Sheryl Windsor, Zhuxuan Fu,Philip Jones,Kenneth Margulies,David Lanfear,Michael J. Nassif,Mansoor Husain,Silvio Inzucchi,Darren Mcguire,
Charles Sherrod,Andrew Sauer, Shachi Patel,Sheryl Windsor,Michael Nassif,Mansoor Husain,Silvio E. Inzucchi,Darren K. McGuire, Bertram Pitt,Benjamin M. Scirica,Bethany Anne Austin,Guillermo Umpierrez,
Journal of the American College of Cardiologyno. 13 (2024): 749
Benjamin W. Lee, Jamie Moni, Nesrine Bouhrira, Alisa N. DeGrave, Noah R. Boone,Elise A. Corbin,Kenneth B. Margulies
CIRCULATION (2023)
CIRCULATION RESEARCHno. Suppl_1 (2023)
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