基本信息
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职业迁徙
个人简介
Research in my lab focuses on the role of interleukin-17 (IL-17) family cytokines in colorectal cancer development and therapeutic intervention. IL-17 plays important roles in immunity against invading pathogens and in chronic inflammation of autoimmune diseases. IL-17 signaling also drives the development of colorectal, breast, pancreatic, and prostate cancers. Our and other people’s previous studies have shown that IL-17 signals to both tumor cells and their environment. Direct engagement of IL-17 promotes tumor cell proliferation and survival, whereas IL-17 signaling on stromal and immune cells seems to promote tumor-associated inflammation and suppress anti-tumor immunity. Despite these breakthroughs, the mechanism by which IL-17 regulates tumor inflammation and immunity response remained largely elusive.
Awards
China Postdoctoral Science Foundation Fellowship China Postdoctoral Science Foundation
Croucher Foundation Fellowship Croucher Foundation
Graduate Admissions Committee Advisory Committee Member UConn Health Local 2017
American Association of Immunologists Professional/Scientific Organization Member External International 2016
Institutional Biosafety Committee Advisory Committee Chair UConn Health Local 2016
American Association for Cancer Research Professional/Scientific Organization Member External International 2014
Awards
China Postdoctoral Science Foundation Fellowship China Postdoctoral Science Foundation
Croucher Foundation Fellowship Croucher Foundation
Graduate Admissions Committee Advisory Committee Member UConn Health Local 2017
American Association of Immunologists Professional/Scientific Organization Member External International 2016
Institutional Biosafety Committee Advisory Committee Chair UConn Health Local 2016
American Association for Cancer Research Professional/Scientific Organization Member External International 2014
研究兴趣
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Ju Chen,Bhaskara Reddy Madina,Elham Ahmadi,Timur Olegovich Yarovinsky, Marie Marthe Krady,Eileen Victoria Meehan, Isabella China Wang,Xiaoyang Ye,Elise Pitmon,Xian-Yong Ma,Bijan Almassian,Valerian Nakaar,
ACTA PHARMACEUTICA SINICA Bno. 1 (2024): 335-349
Jinhyung Lee,Wuxia Zhang,Danh Nguyen,Libo Zhou, Justin Amengual, Jin Zhai, Trystin Cote,Maxwell Landolina,Elham Ahmadi, Ian Sands,Neha Mishra,Hongchuan Yu,
bioRxiv : the preprint server for biology (2024)
Mehdi A Fini,Jenifer A Monks, Min Li,Evgenia Gerasimovskaya, Petr Paucek,Kepeng Wang,Maria G Frid, Steven C Pugliese, Donna Bratton, Yen-Rei Yu,David Irwin,Michael Karin,
bioRxiv : the preprint server for biology (2023)
Sahar Mafi,Elham Ahmadi,Eileen Meehan, Conner Chiari,Behzad Mansoori,Hossein Sadeghi, Sahar Milani,Morteza Jafarinia,Shahram Taeb, Bayan Mafakheri Bashmagh,Seyed Mohammad Ali Mansoorian,Mohammad Sadegh Soltani-Zangbar,
JOURNAL OF IMMUNOLOGYno. 1 (2022)
Xiaoyang Ye,Ju Chen,Jie Pan,Qi Wu,Yue Wang,Mengqian Lu, Chengrong Zhang, Zhenzhen Zhang, Muyan Ma,Jinyong Zhu,Anthony T Vella,Jun Wan,
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