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I am interested in the molecular genetics of essential hypertension and pre-eclampsia, and the role of salt in hypertension.
The recent focus of my group has been the molecular basis of the rare monogenic hypertension syndrome of pseudohypoaldosteronism type 2 (PHA2 or Gordon’s syndrome). PHA2 is inherited as a Mendelian dominant trait with a characteristic phenotype of low-renin (salt-dependent) hypertension and hyperkalaemia. The latter distinguishes it from the other familial forms of hypertension that typically cause low serum potassium.
The recent focus of my group has been the molecular basis of the rare monogenic hypertension syndrome of pseudohypoaldosteronism type 2 (PHA2 or Gordon’s syndrome). PHA2 is inherited as a Mendelian dominant trait with a characteristic phenotype of low-renin (salt-dependent) hypertension and hyperkalaemia. The latter distinguishes it from the other familial forms of hypertension that typically cause low serum potassium.
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JOURNAL OF HUMAN HYPERTENSION (2020)
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Helene Louis-Dit-Picard,Ilektra Kouranti,Chloe Rafael,Irmine Loisel-Ferreira,Maria Chavez-Canales,Waed Abdel Khalek,Eduardo Argaiz,Stephanie Baron,Sarah Vacle, Tiffany Migeon,Richard Coleman,Marcio Do Cruzeiro,
Journal of Clinical Research and Medicine (2018)
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