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Research in the Neve lab is broadly concerned with the function of the brain dopamine system. We use genetically modified dopamine receptors expressed in cells in culture and in mouse brain to explore the effects of dopamine, therapeutic drugs, and abused substances on the receptors and the role of the receptors in dopamine-dependent behaviors. An example of this work is our utilization of in vitro mutagenesis to investigate the interactions of dopamine D2 receptors with agonists and signaling pathway, another is our use of virus-mediated expression of dopamine receptors in vivo to normalize behavior in dopamine receptor knock-out mice. The techniques that we use in these investigations include co-expression and biochemical analysis of a variety of signal transduction molecules (wildtype and mutant receptors, G proteins, effector enzymes), metabolic labeling and immunoprecipitation, confocal fluorescence microscopy, and mouse behavioral assays for the rewarding and aversive properties of abused drugs.
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论文共 173 篇作者统计合作学者相似作者
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Jean‐Martin Beaulieu,Emiliana Borrelli,Arvid Carlsson,Marc G. Caron,Olivier Civelli,Stefano Espinoza, Gilberto Fisone,Raul R. Gainetdinov,David K. Grandy, John W. Kebabian,Saloman Z. Langer,Maria Cristina Missale,
IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
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Molecular Pharmacologyno. 3 (2022): 188-198
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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Dayana Rodriguez-Contreras,Alec Condon, Dave Buck,Naeem Asad,Timothy Dore,Dineke Verbeek,Marina Tijssen, Uiwal Shinde,John Williams,Kim Neve
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