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His research is at the interface between synthetic chemistry, biology, and biophysics; it includes peptide and carbohydrate chemical biology and nanoscience. His research group merges design and chemical synthesis of complex bio-molecules with biophysical chemistry in a unique and powerful manner:
(1) Self-assembly of peptides, small proteins, and peptide-oligonucleotide conjugates at the nanoscale, with a focus on control of protein quaternary structure using non-native ligands and on de novo design of artificial proteins. A key aspect has been the use of small-angle X-ray scattering (SAXS) to study peptide and protein topology, in collaboration with colleagues, thus integrating design, synthesis and structural studies by SAXS.
(2) Peptide medicinal chemistry, in particular peptide hormones such as insulin, Glp-1, and PYY3-36. A focus is on half-life extension through self-organization for the potential treatment of diabetes, obesity, and neurodegenerative diseases.
(3) Enabling several of these projects has been the development of new synthetic methodology and techniques for solid-phase synthesis of peptides with a focus on linkers (handles), instrumentation and use of precise microwave heating.
Research Interests
Papers共 383 篇Author StatisticsCo-AuthorSimilar Experts
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Knud J Jensen, Haoyu Chen,Narendra Kumar Mishra,Manuel C Martos-Maldonado, Sandie B Roholm,Kasper Kildegaard Sørensen
Chembiochem a European journal of chemical biologypp.e202400534-e202400534, (2024)
bioRxiv : the preprint server for biology (2024)
Methods in enzymology (2024): 111-139
JOURNAL OF THE AMERICAN CHEMICAL SOCIETYno. 30 (2023): 16771-16777
The Journal of biological chemistryno. 2 (2023): 102951-102951
JOURNAL OF BIOLOGICAL CHEMISTRYno. 2 (2023)
Shunliang Wu,Mads Ostergaard,Freja Fredholt, Niels Johan Christensen,Kasper K. Sorensen,Narendra K. Mishra,Hanne M. Nielsen,Knud J. Jensen
K. Saatchi, G. Engudar,C. Rodriguez-Rodriguez,N. K. Mishra, M. Bergamo, G. Amouroux,K. J. Jensen,U. O. Hafeli
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Author Statistics
#Papers: 397
#Citation: 8690
H-Index: 44
G-Index: 75
Sociability: 7
Diversity: 4
Activity: 93
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