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1. Regenerative medicine of the cornea using autologous oral mucosa culture epithelial cell sheet transplantation
Allogeneic corneal transplantation has been used to treat a number of diseases including Stevens-Johnson syndrome, ocular pemphigus, etc. This treatment risks rejection and infection, which often lead to poor postoperative results. We have been developing a new transplantation method that involves preparation of the patient’s own mucosal epithelial cell sheets by culturing oral mucosal epithelial cells and have attained promising results in clinical trials [1]. We are currently waiting for approval to use this method as a regenerative medical product.
2. Development of corneal regeneration therapy using iPS cells
We have developed a novel method, SEAM, to differentiate human iPS cells into ocular cells in a manner that mimics whole eye development (Fig. 1 ) [2]. This method can induce corneal epithelial and endothelial cells and has been used to establish clinical application and regenerative medicine of iPS cell-based therapies.
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OPHTHALMIC EPIDEMIOLOGYno. 1 (2024): 46-54
Eye & Contact Lens-science and Clinical Practiceno. 1 (2024): 16-22
STEM CELL REPORTSno. 2 (2024): 254-269
Rumi Kawashima,Kenji Matsushita,Kenji Mandai,Yuko Sugita,Tomohiko Maruo,Kiyohito Mizutani, Yoshihiro Midoh,Akiko Oguchi,Yasuhiro Murakawa, Kazuki Kuniyoshi, Ryohei Sato,Takahisa Furukawa,
iScience (2024)
EUROPEAN JOURNAL OF OPHTHALMOLOGYno. 2 (2024): NP28-NP32
Yoshinori Oie,Shunji Yokokura,Toru Nakazawa,Tomohiko Usui,Shiro Amano,Hiroshi Takayanagi, Shoko Matsubara, Kiyoshi Okada,Takeshi Soma,Takahiro Ogasawara,Masukazu Inoie,Andrew Quantock,
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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