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个人简介
Kris pursued graduate training in Molecular and Cellular Pharmacology at the University of Miami School of Medicine under the mentorship of Izidore Lossos, MD. After receiving his PhD, Kris joined the laboratory of Anthony Letai, MD, PhD, at the Dana-Farber Cancer Institute/ Harvard Medical School for his postdoctoral fellowship.
In collaboration with others in the Letai laboratory, Kris found that some cancer cells are more primed to undergo programmed cell death (apoptosis) than others, as measured by a novel assay called BH3 Profiling (Ni Chonghaile & Sarosiek, et al., Science, 2011). Cancer cells and patient tumors that are more primed to undergo apoptosis are consequently more sensitive to chemotherapy treatment. This finding potentially explains why some patients respond favorably to chemotherapy while others do not. Kris has also utilized BH3 profiling to identify novel interaction preferences among the BCL-2 family of proteins, finding that BID preferentially activates BAK while BIM preferentially activates BAX to trigger apoptosis (Sarosiek, et al., Molecular Cell, 2013)
In collaboration with others in the Letai laboratory, Kris found that some cancer cells are more primed to undergo programmed cell death (apoptosis) than others, as measured by a novel assay called BH3 Profiling (Ni Chonghaile & Sarosiek, et al., Science, 2011). Cancer cells and patient tumors that are more primed to undergo apoptosis are consequently more sensitive to chemotherapy treatment. This finding potentially explains why some patients respond favorably to chemotherapy while others do not. Kris has also utilized BH3 profiling to identify novel interaction preferences among the BCL-2 family of proteins, finding that BID preferentially activates BAK while BIM preferentially activates BAX to trigger apoptosis (Sarosiek, et al., Molecular Cell, 2013)
研究兴趣
论文共 125 篇作者统计合作学者相似作者
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Megan E. Honeywell,Marie S. Isidor, Nicholas W. Harper, Rachel E. Fontana, Gavin A. Birdsall,Peter Cruz-Gordillo, Sydney A. Porto, Madison Jerome,Cameron S. Fraser,Kristopher A. Sarosiek,David A. Guertin,Jessica B. Spinelli,
Nature Chemical Biologypp.1-10, (2024)
Yusuke Matoba, Dominique T. Zarrella,Venkatesh Pooladanda, Maryam Azimi Mohammadabadi,Eugene Kim, Shaan Kumar,Mengyao Xu, Xingping Qin, Lauren J Ray,Kyle M. Devins,Raj Kumar,Artem Kononenko,
British Journal of Cancerpp.1-14, (2024)
Lissah K. Johnson, Maryam Azimi,Xingping Qin,Cameron Fraser,Elizabeth Stover,Yang Yang,Daohong Zhou,Bo Rueda,Kristopher Sarosiek
CANCER RESEARCHno. 5 (2024)
Brendan Shay, Abram Handly-Santana,Xingping Qin, Jonathan Choniere,Kristopher Sarosiek,Joan S. Brugge,Elizabeth H. Stover
Needa Brown,Paul Rocchi, Léna Carmès,Romy Guthier,Meghna Iyer,Léa Seban, Toby Morris,Stephanie Bennett, Michael Lavelle, Johany Penailillo,Ruben Carrasco, Chris Williams,
Theranosticsno. 14 (2023): 4711-4729
CANCER RESEARCHno. 7 (2023)
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Varuna Nangia,Faria M. Siddiqui,Sean Caenepeel,Daria Timonina,Samantha J. Bilton,Nicole Phan,Maria Gomez-Caraballo,Hannah L. Archibald,Chendi Li,Cameron Fraser, Diamanda Rigas, Kristof Vajda,
crossref(2023)
Megan E Honeywell, Marie S Isidor, Nicholas W Harper, Rachel E Fontana,Peter Cruz-Gordillo,Sydney A Porto,Cameron S Fraser,Kristopher A Sarosiek,David A Guertin, Jessica B Spinelli,Michael J Lee
bioRxiv (Cold Spring Harbor Laboratory) (2023)
crossref(2023)
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