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We investigate how complex circuits of genes are regulated to produce robust developmental outcomes particularly during heart development. A main focus is to determine how DNA is packaged into chromatin, and how ATP-dependent chromatin remodelers modify this packaging to control lineage commitment. We are now applying these principles to develop methods to stimulate repair of damaged cardiac tissue (e.g., regeneration). Our ability to combine genomic, genetic, biochemical, and cell biological approaches both in vitro and in vivo as well as ongoing efforts to use tissue engineering to model the 3D architecture of the heart will ultimately allow us to gain a systems level and quantitative understanding of the regulatory circuits that promote normal heart development and how faulty regulation can lead to disease.
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论文共 97 篇作者统计合作学者相似作者
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AMERICAN JOURNAL OF SPORTS MEDICINEno. 2 (2024): 503-515
Chibuikem Iheagwaram,Laurie Boyer
Journal of the American College of Cardiologyno. 13 (2024): 437
John H Day,Pema Maretich,Catherine M Della Santina,Alex L Auld, Kirsten K Schneider,Tay Shin,Edward S Boyden,Laurie A Boyer
biorxiv(2024)
Jordan Whisler,Somayeh Shahreza,Karin Schlegelmilch,Nil Ege,Yousef Javanmardi,Andrea Malandrino,Ayushi Agrawal,Alessandro Fantin, Bianca Serwinski,Hesham Azizgolshani,Clara Park, Victoria Shone,
Shu Hui Neo,Zhisheng Her, Rashidah Othman,Ching Ann Tee, Li Ching Ong, Yuehua Wang, Irwin Tan, Jaylen Tan,Yanmeng Yang,Zheng Yang,Qingfeng Chen,Laurie A. Boyer
bioRxiv : the preprint server for biology (2023)
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CIRCULATION RESEARCHno. 12 (2022): 980-1000
Smitha Surendran Thamarath,Ching Ann Tee, Shu Hui Neo,Dahou Yang, Rashidah Othman,Laurie A. Boyer,Jongyoon Han
biorxiv(2022)
Nature Structural & Molecular Biologyno. 5 (2021): 435-442
biorxiv(2021)
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