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Our research is concerned with the mechanism and regulation of microtubule polymerization and dynamics. Microtubules, major structural components of the cytoskeleton, are critical in cell shape and many types of cell movement. They are composed of the protein tubulin and have associated with their surfaces and ends a wide variety of proteins that regulate polymerization dynamics and function. Energy is released by the hydrolysis of GTP to GDP when tubulin adds to microtubule ends, that gives rise to growing and shortening transitions at the ends (called dynamic instability) and opposite end assembly and disassembly (treadmilling). Our work is aimed at understanding the mechanism and the regulation of these dynamic behaviors in relation to (a) mitosis in cancer cells and the mechanisms of action of microtubule-targeted anticancer drugs, and (b) the mechanisms of actions of microtubule regulatory proteins in neuronal cells such as the tau proteins and microtubule plus-tip tracking proteins.
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论文共 212 篇作者统计合作学者相似作者
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Leslie Wilson, Anne F. Gress,Lynda Frassetto,Harini Sarathy, Elizabeth A. Gress,William H. Fissell,Shuvo Roy
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGYno. 1 (2024): 76-84
Leslie Wilson,Alina Denham,Yelena Ionova,Conor O'Neill,Carol M. Greco,Afton L. Hassett,Janel Hanmer, Sana Shaikh, Mehling Wolf, Sigurd Berven,David Williams,Yanlei Ma,
PM&R (2024)
Leslie Wilson,Patricia Zheng, Yelena Ionova, Alina Denham, Connie Yoo,Yanlei Ma,Carol M Greco,Janel Hanmer,David A Williams,Afton L Hassett, Aaron Wolfe Scheffler,Frank Valone,
Pain Medicine (2023)
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PAIN MEDICINEno. 8 (2023): 963-973
Kimberly Badal, James Staib,Jeffrey Tice,Mi-Ok Kim,Martin Eklund,Stacey DaCosta Byfield, Kierstin Catlett,Leslie Wilson, Liz Maffey,Rashna Soonavala, Allison Stover-Fiscalini,Laura Esserman
JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023): e18917-e18917
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biorxiv(2022)
European Journal of Cancer Careno. 6 (2022)
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