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The long-term goal of our research is to develop safe and effective therapeutics for CNS disorders such as Alzheimer’s disease (AD) and related dementias and acute brain injuries (ICH, TBI) by targeting dysregulated neuroinflammation in the brain. The focus is on identification of signal transduction pathways that mediate the neuroinflammatory responses of activated astrocytes and microglia, and determination of how aberrant glial-neuronal interactions influence neurodegenerative processes. When injury or change occurs in the brain, glia mount a beneficial activation response to fight off the insult and restore the brain to its proper functioning. While a controlled activation response is important in protecting the brain, this beneficial process sometimes gets out of balance and the activation becomes too strong or too prolonged. In CNS diseases, glia are over-activated, producing detrimental proinflammatory cytokines that can contribute to neuron damage and accelerate disease progression. We have developed selective, small molecule experimental therapeutics that suppress proinflammatory cytokine overproduction, and we are developing them into effective future drugs. Most recently, our collaborative studies have resulted in the discovery of new classes of orally active, CNS-penetrant, small molecule drug candidates that modulate glia dysfunction with resultant attenuation of neuropathology progression in animal models. These novel small molecules are candidates for drug development as well as tools to explore the potential of improved neurologic outcomes by restoration of activated glia back towards homeostasis. For example, in collaborative efforts at the biology-chemistry interface, we have shepherded a set of small molecule compounds from design and synthesis, through IND-enabling preclinical development. This led to successful phase I clinical trials with three of our compounds, which are currently being moved into further clinical development.
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论文共 297 篇作者统计合作学者相似作者
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Pinar Coskun,Justin Barber,Erin L. Abner,Richard J. Kryscio,Frederick A. Schmitt, Larry Goldstein,Linda J. Van Eldik,Peter T. Nelson,Gregory A. Jicha
Alzheimer's & Dementiano. 17_supplement_1 (2024)
Hilaree N. Frazier,David J. Braun, Caleb S. Bailey, Meggie J. Coleman, Verda A. Davis, Stephen R. Dundon, Christopher J. McLouth, Hana C. Muzyk,David K. Powell,Colin B. Rogers,Saktimayee M. Roy,Linda J. Van Eldik
Brain, Behavior, & Immunity - Health (2024): 100826-100826
Maria A. Telpoukhovskaia, Thomas J. Murdy,Olivia J. Marola, Kevin Charland,Michael MacLean,Tain Luquez, Alexandra M. Lish,Sarah Neuner,Amy Dunn,Kristen D. Onos,Jesse Wiley,Derek Archer,Matthew J. Huentelman,Matthias Arnold,Vilas Menon,Alison Goate,Linda J. Van Eldik,Paul R. Territo,Gareth R. Howell,Gregory W. Carter,Kristen M. S. O'Connell,Catherine C. Kaczorowski, the JAX CADR Workshop
Alzheimer’s & Dementia Translational Research & Clinical Interventionsno. 1 (2024): n/a-n/a
Statistica Neerlandicano. 3 (2023): 304-321
Alzheimer's & dementia (Amsterdam, Netherlands)no. 2 (2023): e12437-e12437
Farid Rajabli,Penelope Benchek,Giuseppe Tosto,Nicholas A. Kushch, Sha Jiang,Katrina Bazemore,Congcong Zhu,Wan‐Ping Lee,Jacob Haut,Kara L. Hamilton‐Nelson,Nicholas R. Wheeler,Yi Zhao,John Farrell,Michelle Grunin,Yuk Yee Leung,Pavel P. Kuksa,Donghe Li,Eder Lúcio da Fonseca,Jesse Mez,Ellen L. Palmer,Jagan A. Pillai,Richard Sherva,Yeunjoo E. Song,Xiaoling Zhang,Taha Iqbal,Omkar Pathak,Otto Valladares,Amanda B. Kuzma,Erin L. Abner,Perrie M. Adams,Alyssa Aguirre,Marilyn Albert,Roger L. Albin,Mariet Allen,Luis Alvarez,Liana G. Apostolova,Steven E. Arnold,Sanjay Asthana,Craig S. Atwood, Gayle Ayres,Clinton T. Baldwin,Robert C. Barber,Lisa L. Barnes,Sandra Barral,Thomas G. Beach,James T. Becker,Gary W. Beecham,Duane Beekly,Bruno A. Benitez,David A. Bennett,John Bertelson,Thomas D. Bird,Deborah Blacker,Bradley F. Boeve,James D. Bowen,Adam L. Boxer,James B. Brewer,James R. Burke,Jeffrey M. Burns,Joseph D. Buxbaum,Nigel J. Cairns,Laura B. Cantwell,Chuanhai Cao,Christopher S. Carlson,Cynthia M. Carlsson,Regina M. Carney,Minerva M. Carrasquillo,Scott A. Chasse,Marie‐Françoise Chesselet,Nathaniel A. Chin,Helena C. Chui,Jaeyoon Chung,Suzanne Craft,Paul K. Crane,David H. Cribbs,Elizabeth Crocco,Carlos Cruchaga,Michael L. Cuccaro,Munro Cullum,Eveleen Darby,Barbara Davis,Philip L. De Jager,Charles DeCarli,John C. DeToledo,Malcolm Dick,Dennis W. Dickson,Beth A. Dombroski,Rachelle S. Doody,Ranjan Duara,Nilüfer Ertekin-Taner,Denis A. Evans,Kelley Faber,Thomas J. Fairchild,Kenneth B. Fallon,David W. Fardo,Martin R. Farlow, Victoria Fernandez-Hernandez,Steven H. Ferris,Tatiana Foroud,Matthew P. Frosch,Brian Fulton‐Howard,Douglas Galasko,Adriana C. Gamboa,Marla Gearing,Daniel H. Geschwind,Bernardino Ghetti,John R. Gilbert,Alison Goate,Thomas J. Grabowski,Neill R. Graff‐Radford,Robert C. Green,John H. Growdon,Hákon Hákonarson,James Hall,Ronald L. Hamilton,Oscar Harari,John Hardy,Lindy E. Harrell,Elizabeth Head,Victor W. Henderson,Michelle Hernández,Timothy J. Hohman,Lawrence S. Honig,Ryan M. Huebinger,Matthew J. Huentelman,Christine M. Hulette,Bradley T. Hyman,Linda S. Hynan,Laura Ibáñez,Gail P. Jarvik,Suman Jayadev,Lee‐Way Jin, Kurt E. Johnson,Leigh Johnson,M. Ilyas Kamboh,Anna Karydas,Mindy J. Katz,John S. K. Kauwe,Jeffrey Kaye,C. Dirk Keene,Aisha Khaleeq,Ronald Kim,Janice Knebl,Neil W. Kowall,Joel H. Kramer,Walter A. Kukull,Frank M. LaFerla,James J. Lah,Eric B. Larson,Alan J. Lerner,James B. Leverenz,Aĺlan I. Levey,Andrew P. Lieberman,Richard B. Lipton,Mark W. Logue,Oscar L. López,Kathryn L. Lunetta,Constantine G. Lyketsos,Douglas A. Mains,Flanagan E. Margaret,Daniel C. Marson,Eden R. Martin,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Paul J. Massman,Arjun V. Masurkar,Wayne C. McCormick,Susan M. McCurry,Andrew McDavid, Stefan I. McDonough,Ann C. McKee,Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Thomas J. Montine,Edwin S. Monuki,John C. Morris,Shubhabrata Mukherjee,Amanda Myers, Trung Dung Nguyen,Sid O’Bryant,John Olichney, Marcia G. Ory,Raymond F. Palmer,Joseph E. Parisi,Henry L. Paulson,Valory N. Pavlik,David Paydarfar,Victoria Pérez,Elaine R. Peskind,Ronald C. Petersen,Aimee Pierce,Marsha J. Polk,Wayne W. Poon,Huntington Potter,Liming Qu,Mary Quiceno,Joseph F. Quinn,Ashok Raj,Murray A. Raskind,Eric M. Reiman,Barry Reisberg,Joan Reisch,John M. Ringman,Erik D. Roberson, Monica Rodriguear,Ekaterina Rogaeva, Howard J. Rosen,Roger N. Rosenberg,Donald R. Royall,Mark A. Sager,Mary Sano,Andrew J. Saykin,Julie A. Schneider,Lon S. Schneider,William W. Seeley,Susan H. Slifer,Scott A. Small,Amanda Smith,Janet P. Smith,Joshua A. Sonnen,Salvatore Spina,Peter St George-Hyslop,Robert A. Stern,Alan Stevens,Stephen M. Strittmatter,David L. Sultzer,Russell H. Swerdlow,Rudolph E. Tanzi,Jeffrey L. Tilson,John Q. Trojanowski,Juan C. Troncoso,Debby W. Tsuang,Vivianna M. Van Deerlin,Linda J. Van Eldik,Jeffery M. Vance,Badri N. Vardarajan,Robert Vassar,Harry V. Vinters,Jean‐Paul Vonsattel,Sandra Weıntraub,Kathleen A. Welsh‐Bohmer,Patrice L. Whitehead,Ellen M. Wijsman,Kirk C. Wilhelmsen,Benjamin Williams,Jennifer Williamson,Henrik Wilms,Thomas S. Wingo,Thomas Wısnıewskı,Randall L. Woltjer, Martin Woon,Clinton B. Wright,Chuang‐Kuo Wu,Steven G. Younkin,Chang‐En Yu,Lei Yu,Xiongwei Zhu,Brian W. Kunkle,William S. Bush,Li-San Wang,Lindsay A. Farrer,Jonathan L. Haines,Richard Mayeux,Margaret A. Pericak‐Vance,Gerard D. Schellenberg,Gyungah Jun,Christiane Reitz,Adam C. Naj
medRxiv (Cold Spring Harbor Laboratory) (2023)
Acta neuropathologica communicationsno. 1 (2023)
BRAIN COMMUNICATIONSno. 5 (2023)
David J. Braun,Hilaree N. Frazier,Verda A. Davis, Meggie J. Coleman,Colin B. Rogers,Linda J. Van Eldik
PloS oneno. 5 (2023): e0286495-e0286495
Farid Rajabli,Penelope Benchek,Giuseppe Tosto,Nicholas Kushch,Jin Sha,Katrina Bazemore,Congcong Zhu,Wan-Ping Lee,Jacob Haut,Kara L Hamilton-Nelson,Nicholas R Wheeler,Yi Zhao,John J Farrell,Michelle A Grunin,Yuk Yee Leung,Pavel P Kuksa,Donghe Li,Eder Lucio da Fonseca,Jesse B Mez,Ellen L Palmer,Jagan Pillai,Richard M Sherva,Yeunjoo E Song,Xiaoling Zhang,Taha Iqbal,Omkar Pathak,Otto Valladares,Amanda B Kuzma,Erin Abner,Perrie M Adams,Alyssa Aguirre,Marilyn S Albert,Roger L Albin,Mariet Allen,Lisa Alvarez,Liana G Apostolova,Steven E Arnold,Sanjay Asthana,Craig S Atwood, Gayle Ayres,Clinton T Baldwin,Robert C Barber,Lisa L Barnes,Sandra Barral,Thomas G Beach,James T Becker,Gary W Beecham,Duane Beekly,Bruno A Benitez,David Bennett,John Bertelson,Thomas D Bird,Deborah Blacker,Bradley F Boeve,James D Bowen,Adam Boxer,James Brewer,James R Burke,Jeffrey M Burns,Joseph D Buxbaum,Nigel J Cairns,Laura B Cantwell,Chuanhai Cao,Christopher S Carlson,Cynthia M Carlsson,Regina M Carney,Minerva M Carrasquillo,Scott Chasse,Marie-Francoise Chesselet,Nathaniel A Chin,Helena C Chui,Jaeyoon Chung,Suzanne Craft,Paul K Crane,David H Cribbs,Elizabeth A Crocco,Carlos Cruchaga,Michael L Cuccaro,Munro Cullum,Eveleen Darby,Barbara Davis,Philip L De Jager,Charles DeCarli,John DeToledo,Malcolm Dick,Dennis W Dickson,Beth A Dombroski,Rachelle S Doody,Ranjan Duara,NIlüfer Ertekin-Taner,Denis A Evans,Kelley M Faber,Thomas J Fairchild,Kenneth B Fallon,David W Fardo,Martin R Farlow, Victoria Fernandez-Hernandez,Steven Ferris,Tatiana M Foroud,Matthew P Frosch,Brian Fulton-Howard,Douglas R Galasko,Adriana Gamboa,Marla Gearing,Daniel H Geschwind,Bernardino Ghetti,John R Gilbert,Alison M Goate,Thomas J Grabowski,Neill R Graff-Radford,Robert C Green,John H Growdon,Hakon Hakonarson,James Hall,Ronald L Hamilton,Oscar Harari,John Hardy,Lindy E Harrell,Elizabeth Head,Victor W Henderson,Michelle Hernandez,Timothy Hohman,Lawrence S Honig,Ryan M Huebinger,Matthew J Huentelman,Christine M Hulette,Bradley T Hyman,Linda S Hynan,Laura Ibanez,Gail P Jarvik,Suman Jayadev,Lee-Way Jin,Kim Johnson,Leigh Johnson,M Ilyas Kamboh,Anna M Karydas,Mindy J Katz,John S Kauwe,Jeffrey A Kaye,C Dirk Keene,Aisha Khaleeq,Ronald Kim,Janice Knebl,Neil W Kowall,Joel H Kramer,Walter A Kukull,Frank M LaFerla,James J Lah,Eric B Larson,Alan Lerner,James B Leverenz,Allan I Levey,Andrew P Lieberman,Richard B Lipton,Mark Logue,Oscar L Lopez,Kathryn L Lunetta,Constantine G Lyketsos,Douglas Mains,Flanagan E Margaret,Daniel C Marson, R,Frank Martiniuk,Deborah C Mash,Eliezer Masliah,Paul Massman,Arjun Masurkar,Wayne C McCormick,Susan M McCurry,Andrew N McDavid, Stefan McDonough,Ann C McKee,Marsel Mesulam,Bruce L Miller,Carol A Miller,Joshua W Miller,Thomas J Montine,Edwin S Monuki,John C Morris,Shubhabrata Mukherjee,Amanda J Myers, Trung Nguyen,Sid O'Bryant,John M Olichney,Marcia Ory,Raymond Palmer,Joseph E Parisi,Henry L Paulson,Valory Pavlik,David Paydarfar,Victoria Perez,Elaine Peskind,Ronald C Petersen,Aimee Pierce,Marsha Polk,Wayne W Poon,Huntington Potter,Liming Qu,Mary Quiceno,Joseph F Quinn,Ashok Raj,Murray Raskind,Eric M Reiman,Barry Reisberg,Joan S Reisch,John M Ringman,Erik D Roberson, Monica Rodriguear,Ekaterina Rogaeva, Howard J Rosen,Roger N Rosenberg,Donald R Royall,Mark A Sager,Mary Sano,Andrew J Saykin,Julie A Schneider,Lon S Schneider,William W Seeley,Susan H Slifer,Scott Small,Amanda G Smith,Janet P Smith,Joshua A Sonnen,Salvatore Spina,Peter St George-Hyslop,Robert A Stern,Alan B Stevens,Stephen M Strittmatter,David Sultzer,Russell H Swerdlow,Rudolph E Tanzi,Jeffrey L Tilson,John Q Trojanowski,Juan C Troncoso,Debby W Tsuang,Vivianna M Van Deerlin,Linda J van Eldik,Jeffery M Vance,Badri N Vardarajan,Robert Vassar,Harry V Vinters,Jean-Paul Vonsattel,Sandra Weintraub,Kathleen A Welsh-Bohmer,Patrice L Whitehead,Ellen M Wijsman,Kirk C Wilhelmsen,Benjamin Williams,Jennifer Williamson,Henrik Wilms,Thomas S Wingo,Thomas Wisniewski,Randall L Woltjer, Martin Woon,Clinton B Wright,Chuang-Kuo Wu,Steven G Younkin,Chang-En Yu,Lei Yu,Xiongwei Zhu,Brian W Kunkle,William S Bush,Li-San Wang,Lindsay A Farrer,Jonathan L Haines,Richard Mayeux,Margaret A Pericak-Vance,Gerard D Schellenberg,Gyungah R Jun,Christiane Reitz,Adam C Naj
medRxiv the preprint server for health sciences (2023)
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作者统计
#Papers: 296
#Citation: 21053
H-Index: 78
G-Index: 141
Sociability: 8
Diversity: 3
Activity: 34
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