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Lisa Carey’s research interests focus upon breast cancer, including examination of different subtypes of breast cancer, evaluation of new chemotherapy agents in early and metastatic breast cancer, and examination of tumor characteristics that predict response to therapy.
She has worked extensively with scientists across UNC Lineberger and the UNC Gillings Global School of Public Health to better understand and characterize the molecular subtypes of breast cancer so that we may develop better prevention and treatment strategies. With Drs. Perou and Millikan, she identified the elevated risk of the poor-prognosis basal-like breast cancer subtype in young African-American women. She is a world-wide expert in triple negative breast cancer, and led the first trial looking at a new drug regimen in this breast cancer subtype.
Her research spans the spectrum from early curative breast cancer to metastatic disease. She has worked extensively developing trials that use neoadjuvant, or preoperative, chemotherapy for breast cancer in order to address both clinical questions about the best regimens, as well as scientific questions regarding sensitivity or resistance to drugs. She led a large NCI-sponsored trial in HER2-positive breast cancer that examined dual HER2-targeting with two anti-HER2 drugs that found that while drug regimen was important in outcome, even more important were tumor characteristics such as subtype and evidence of immune cell activation. Based on this work, she has put together an international team looking at the molecular markers responsible this variation in response and survival, and her efforts as co-chair of the national cooperative group, Alliance, have resulted in two NCI trials examining these markers and optimizing treatment. In addition, she is actively involved in examining novel agents in metastatic breast cancer. Her Tumor Donation Program has contributed novel information regarding the genetic differences between the original primary breast cancer and the metastases in distant organs. This work in part spawned the AURORA-US multicenter initiative furthering this examination of the molecular landscape of metastatic disease; she serves on the Steering Committee for that effort.
She serves in national leadership roles, including as a member of the National Cancer Institute Breast Cancer Steering Committee, Co-Chair of the NCI-sponsored Alliance Breast Committee, Co-Chair of the Translational Breast Cancer Research Consortium Steering Committee, and member of the Board of Directors of the American Society of Clinical Oncology.
研究兴趣
论文共 492 篇作者统计合作学者相似作者
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JAMA ONCOLOGY (2024)
Aranzazu Fernandez-Martinez,Mattia Rediti,Gong Tang,Tomás Pascual, Katherine A Hoadley,David Venet,Naim U Rashid,Patricia A Spears,Md N Islam, Sarra El-Abed,Judith Bliss,Matteo Lambertini,
JAMA oncology (2024)
Clinical cancer research : an official journal of the American Association for Cancer Researchno. 4 (2024): 793-802
JAMA oncologyno. 3 (2024): 362-371
CANCERno. 5 (2024): 750-769
The Lancet Oncologyno. 4 (2024): e139-e151
Aranzazu Fernandez-Martinez,Mattia Rediti, Gong Tang,Tomás Pascual, Katherine A. Hoadley,David Venet,Naim U. Rashid,Patricia A. Spears,Md N. Islam, Sarra El-Abed,Judith Bliss,Matteo Lambertini,
JAMA Oncology (2024)
Aleix Prat,Nadia Solovieff, Fabrice Andre, Joyce O'Shaughnessy,David A. Cameron,Wolfgang Janni,Gabe S. Sonke,Yoon-Sim Yap,Denise A. Yardley,Ann H. Partridge,Astrid Thuerigen,Juan Pablo Zarate,
CLINICAL CANCER RESEARCHno. 4 (2024): 793-802
Tomás Pascual,Aranzazu Fernandez-Martinez,Maki Tanioka, M. Vittoria Dieci,Sonia Pernas,Joaquin Gavila,Valentina Guarneri,Javier Cortes,Patricia Villagrasa,Núria Chic, Maria Vidal,Barbara Adamo,
crossref(2024)
Aditya Bardia,Hope S Rugo,Sara M Tolaney, Delphine Loirat,Kevin Punie,Mafalda Oliveira,Adam Brufsky,Kevin Kalinsky,Javier Cortés, Joyce O' Shaughnessy, Véronique Diéras,Lisa A Carey,
Journal of clinical oncology : official journal of the American Society of Clinical Oncologypp.JCO2301409-JCO2301409, (2024)
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