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个人简介
Dr. Smith's research accomplishments include the development and standardization of the mouse model of oxygen-induced retinopathy; basic mechanisms of vascular growth and translation to the clinic via VEGF; growth hormone and insulin-like growth factor in retinopathy; the role of omega-3 and omega-6 polyunsaturated fatty acids and other lipids in photoreceptor metabolism driving angiogenesis; and photoreceptor energy deficiency as cause of neovascular AMD. Dr. Smith's notable recent accomplishments include development of mitochondrial functional mapping of the retina and optic nerve; development of FGF21 as a treatment for diseases with depressed mitochondrial function, including retinal degenerations (retinitis pigmentosa), AMD, diabetic retinopathy, and ROP; the development of GPR40 and GPR120 as targets for improving mitochondrial function in disease; and SOCS3 as a modulator of inflammation in photoreceptor signaling.
研究兴趣
论文共 439 篇作者统计合作学者相似作者
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The Lancet Regional Health - Europe (2023): 100696-100696
The American journal of clinical nutritionno. 3 (2023): 579-590
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JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICSno. 8 (2023): A115-A115
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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Hitomi Yagi,Myriam Boeck, Katherine Neilsen,Jay Yang,Minji Ko,Yohei Tomita,Zhongjie Fu,Saswata Talukdar,Ye Sun,Lois Smith
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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Myriam Boeck,Hitomi Yagi, Katherine Neilsen,Jay Yang,Minji Ko,Anders K Nilsson,Ann Hellström,Zhongjie Fu,Lois EH Smith
Current Developments in Nutrition (2023): 101001-101001
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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Gael Cagnone,Sheetal Pundir, Jin Sung-Kim,Jose Carlos Rivera,Tapan Agnihotri, Noemie-Rose Harvey,Emilie Heckel,Charlotte Betus,Mei Xi Chen, Anu Situ,Perrine Gaub,Nicholas Kim,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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