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个人简介
Li’s research is focused on understanding how small RNA molecules function in the nucleus of mammalian cells to regulate gene transcription and epigenetic memory, and the potential implications of such regulatory mechanisms in disease especially cancer. His seminal work on the identification of RNA activation (RNAa) demonstrates that promoter-targeted small RNAs are able to activate gene expression. Ongoing research in Li’s laboratory includes (1) understanding the molecular mechanism of RNAa by using a combination of genomic, bioinformatic, and molecular biology approaches, (2) identifying interactions of small RNA with the genome and analyzing their functional roles in normal cellular processes and in cancer development at a genome-wide scale, (3) exploiting the RNAa mechanism for the treatment of cancer through targeted activation of tumor suppressor genes, and (4) for cell fate reprogramming.
研究兴趣
论文共 154 篇作者统计合作学者相似作者
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Chunling Duan,Moorim Kang, Xiaojie Pan,Zubao Gan,Vera Huang, Guanlin Li,Robert F. Place,Long-Cheng Li
Molecular Therapy - Nucleic Acidsno. 1 (2024): 102147-102147
Chunling Duan,Moorim Kang, Kunshan Liu,Zubao Gan, Guanlin Li, Junnan Chen, Ian Schacht, Robert F. Place,Long-Cheng Li
biorxiv(2023)
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Chunling Duan,Moorim Kang, Xiaojie Pan,Zubao Gan,Vera Huang, Guanlin Li,Robert F. Place,Long-Cheng Li
biorxiv(2023)
crossref(2023)
crossref(2023)
crossref(2023)
Chunling Duan, Moorim Kang, Xiaojie Pan, Zubao Gan,Vera Huang, Guanlin Li,Robert F. Place,Long-Cheng Li
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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