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Dr. Isom’s research program at the University of Michigan focuses on voltage-gated sodium channel function and the roles of sodium channel gene variants in developmental and epileptic encephalopathy (DEE), including Dravet syndrome. Her lab investigates SCN1A, SCN1B, and SCN8A DEE variants in mouse models and in human induced pluripotent stem cell (iPSC) neurons and cardiac myocytes. Dr. Isom showed, in collaboration with Dr. Jack Parent, that the high risk of SUDEP in Dravet syndrome may result from a predisposition to cardiac arrhythmias in addition to neuronal hyperexcitability, reflecting haploinsufficiency of SCN1A in heart and brain and the resulting compensatory overexpression of other sodium channel genes in those tissues. Their work predicted cardiac abnormalities in a Dravet syndrome patient prior to clinical evaluation. Most recently, she has collaborated with Stoke Therapeutics to develop the first antisense oligonucleotide precision therapeutic agent for Dravet syndrome, which is now in clinical trials. Dr. Isom is Co-PI of the NINDS-funded EpiMVP Center Without Walls.
Dr. Isom serves as PI of the NIH funded, Pharmacological Sciences Training Program T32 grant. She co-chairs the Dravet Syndrome Foundation Scientific Advisory Board, served a three-year term on the Board of the American Epilepsy Society (AES) and now co-chairs the AES/NINDS Benchmarks Committee, and serves on the International League Against Epilepsy ILAE) Translational Task Force, the Epilepsy Action Network, and Partners Against Mortality in Epilepsy (PAME). She chaired the NIH ESTA study section, and serves on editorial boards of scientific journals. She has received awards for research and mentoring, including her current NINDS Javits R37 MERIT award and the University of Michigan Rackham Distinguished Graduate Mentoring Award. She is a Fellow of the American Association for the Advancement of Science, a Fellow of the American Society for Pharmacology and Experimental Therapeutics, and a Fellow of the American Epilepsy Society. Dr. Isom was elected to the National Academy of Medicine in 2021 and received the American Epilepsy Society Basic Science Award in 2022.
Dr. Isom serves as PI of the NIH funded, Pharmacological Sciences Training Program T32 grant. She co-chairs the Dravet Syndrome Foundation Scientific Advisory Board, served a three-year term on the Board of the American Epilepsy Society (AES) and now co-chairs the AES/NINDS Benchmarks Committee, and serves on the International League Against Epilepsy ILAE) Translational Task Force, the Epilepsy Action Network, and Partners Against Mortality in Epilepsy (PAME). She chaired the NIH ESTA study section, and serves on editorial boards of scientific journals. She has received awards for research and mentoring, including her current NINDS Javits R37 MERIT award and the University of Michigan Rackham Distinguished Graduate Mentoring Award. She is a Fellow of the American Association for the Advancement of Science, a Fellow of the American Society for Pharmacology and Experimental Therapeutics, and a Fellow of the American Epilepsy Society. Dr. Isom was elected to the National Academy of Medicine in 2021 and received the American Epilepsy Society Basic Science Award in 2022.
研究兴趣
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NATURE NEUROSCIENCEpp.1-2, (2024)
Brain : a journal of neurology (2023)
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Andrew M Tidball,Wei Niu,Qianyi Ma, Taylor N Takla, J Clayton Walker, Joshua L Margolis,Sandra P Mojica-Perez, Roksolana Sudyk,Lu Deng,Shannon J Moore,Ravi Chopra,Vikram G Shakkottai,
Stem cell reportsno. 12 (2023): 2498-2514
Yukun Yuan,Luis Lopez-Santiago,Nicholas Denomme,Chunling Chen, Heather A. O'Malley,Samantha L. Hodges, Sophina Ji,Zhou Han, Anne Christiansen,Lori L. Isom
BRAIN (2023)
Chunling Chen,Julie Ziobro, Larissa Robinson-Cooper,Samantha L. Hodges, Yan Chen,Nnamdi Edokobi,Luis Lopez-Santiago, Karl Habig, Chloe Moore, Joe Minton, Sabrina Bramson, Caroline Scheuing,
Brain Communicationsno. 6 (2023): fcad283-fcad283
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
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Neuronno. 9 (2023): 1440-1452.e5
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