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The overall goal of our research is to unravel the mechanisms that allow bacteria to adapt and differentiate in response to changes in the environment. Bacteria have evolved at least three strategies that allow them to cope with such changes. One strategy centers on changes in gene expression ranging from changes in the expression of relatively few genes to changes in the expression of large numbers of genes culminating in cell differentiation. A second strategy centers on changes in the motility behavior of cells. Finally, a third strategy centers on changes to the cell cycle. To implement these strategies bacterial cells have to process vast amounts of information and then generate the appropriate output response. Information processing is carried out by complex networks of signal transduction proteins. A challenging problem in bacterial adaptation and differentiation is to understand how these protein networks are organized in space and time to allow the ordered execution of various tasks.
The overall goal of our research is to unravel the mechanisms that allow bacteria to adapt and differentiate in response to changes in the environment. Bacteria have evolved at least three strategies that allow them to cope with such changes. One strategy centers on changes in gene expression ranging from changes in the expression of relatively few genes to changes in the expression of large numbers of genes culminating in cell differentiation. A second strategy centers on changes in the motility behavior of cells. Finally, a third strategy centers on changes to the cell cycle. To implement these strategies bacterial cells have to process vast amounts of information and then generate the appropriate output response. Information processing is carried out by complex networks of signal transduction proteins. A challenging problem in bacterial adaptation and differentiation is to understand how these protein networks are organized in space and time to allow the ordered execution of various tasks.
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PLOS BIOLOGYno. 1 (2024): e3002454-e3002454
Michel Oklitschek,Luís António Menezes Carreira, Memduha Muratoğlu,Lotte Søgaard-Andersen,Anke Treuner-Lange
biorxiv(2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 17 (2024): e2321989121-e2321989121
Nature communicationsno. 1 (2023): 3825-24
bioRxiv (Cold Spring Harbor Laboratory) (2023)
STAR Protocolsno. 4 (2023): 102657-102657
Nature communicationsno. 1 (2023): 4056-17
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