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职业迁徙
个人简介
Marraffini uses Staphylococcus epidermidis and Streptococcus pyogenes as model systems for studying CRISPR immunity. The clinical isolate S. epidermidis RP62a harbors a CRISPR spacer that matches the nickase gene (nes) that is present in nearly all staphylococcal conjugative plasmids and prevents their spread. Using this system, Marraffini revealed that the CRISPR-Cas machinery targets DNA, rather than RNA, directly. Work in the Marraffini lab also demonstrated that the S. pyogenes crRNA-guided Cas9 DNA nuclease constitute a formidable tool for genetic engineering.
Marraffini’s current research employs molecular genetic and biochemical approaches to analyze the genesis and function of CRISPR-Cas systems. He ultimately hopes to answer fundamental questions about how CRISPR-Cas systems destroy their targets, how the genetic memory is generated, and how CRISPR-Cas immunity affects the evolution of bacteria and archaea.
Awards
RNA Society Award, 2010
Searle Scholar, 2011
Rita Allen Foundation Scholar, 2012
NIH Director’s New Innovator Award, 2012
The Rockefeller University Distinguished Teaching Award, 2013
40 Under 40, Cell, 2014
Hans Sigrist Prize, 2015
Earl and Thressa Stadtman Scholar Award, 2016
Howard Hughes Medical Institute Faculty Scholar, 2016
Albany Medical Center Prize in Medicine and Biomedical Research, 2017
Gabrielle H. Reem and Herbert J. Kayden Early-Career Innovation Award, 2017
NIH Director’s Pioneer Award, 2017
Max Planck-Humboldt Medal, 2020
研究兴趣
论文共 144 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Dalton V. Banh, Cameron G. Roberts,Adrian Morales-Amador, Brandon A. Berryhill,Waqas Chaudhry,Bruce R. Levin,Sean F. Brady,Luciano A. Marraffini
biorxiv(2024)
TRENDS IN BIOCHEMICAL SCIENCESno. 1 (2024): 28-37
Natureno. 7996 (2024): 1-8
Amer A Hossain, Ying Z Pigli, Christian F Baca,Søren Heissel, Alexis Thomas,Vincent K Libis,Ján Burian, Joshua S Chappie,Sean F Brady,Phoebe A Rice,Luciano A Marraffini
Naturepp.1-7, (2024)
Claire T Kenney,Luciano A Marraffini
Nucleic acids researchno. 14 (2023): 7438-7450
Dalton V Banh, Cameron G Roberts,Adrian Morales-Amador, Brandon A Berryhill,Waqas Chaudhry,Bruce R Levin,Sean F Brady,Luciano A Marraffini
Natureno. 7989 (2023): 1001-1008
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
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