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For over 30 years, the research of M Grounds has focussed on factors controlling the repair of damaged skeletal muscle and on potential treatments for muscle diseases such as Duchenne’s muscular dystrophy and muscle wasting, with a focus on in vivo studies and tissue analyses. Her research has pioneered many studies into factors controlling skeletal muscle regeneration with a particular emphasis on myogenesis in post-natal skeletal muscle in vivo, and an ongoing interest in the role of the extracellular matrix. Research on cell therapies developed the Y-chromosome probe for tracking male nuclei and identified the massive and rapid death of injected donor cells in Myoblast Transfer Therapy. Other projects investigate stem cell therapies (MG published the first bone-marrow reconstitution experiments to look for bone-marrow derived muscle stem cells in 1983) and Tissue Engineering for skeletal and cardiac muscle. Current research includes the in vivo role of IGF-1 isoforms, a focus on inflammation and anti-cytokine therapies, metabolism, and oxidative stress, all with applications to skeletal muscle wasting with ageing, muscular dystrophy and especially age-related loss of muscle mass and function (Sarcopenia).
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CLINICAL SCIENCEno. 22 (2023): 1721-1751
Metabolitesno. 2 (2023): 232-232
Acta physiologica (Oxford, England)no. 4 (2023)
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Tomohito Iwasaki,Jessica R Terrill, Kei Kawarai, Yusei Miyata,Takayoshi Tagami,Naoyuki Maeda,Yasuhiro Hasegawa,Takafumi Watanabe,Miranda D Grounds,Peter G Arthur
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