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个人简介
Paolo Comoglio has a long and distinguished record in the field of research on tyrosine kinase receptors and related oncogenes. He developed the first anti-phosphotyrosine antibody (Comoglio et al. 1984, EMBO J. 3:483-9); by this tool he identified the tyrosine kinase encoded by the rearranged Bcr-Abl oncogene, responsible for the onset of Chronic Myeloid Leukemia (Mol Cell Biol. 1986; 6:1803-11.)
He focused his research efforts on the full mechanistic insight of the genetic, biochemistry and biology of the Met receptor, with a special emphasis on the role of this oncogene in human cancers. After a long standing career he is now acknowledged as a leader in the field.
He identified the tyrosine kinase receptor encoded by the Met oncogene (Nature. 1989; 339:155-6.) and discovered that Hepatocyte Growth Factor (HGF) is the cognate ligand (Oncogene. 1991; 6:501-4.)
He identified and elucidated the functions of three tyrosine kinase receptors, encoded by genes structurally and functionally related to Met : Ron, (EMBO J. 1994; 13:3524-32), Plexins (Cell. 1999; 99:71-80) and Ror ( Cancer Res. 2011; 71:3132-41).
He focused his research efforts on the full mechanistic insight of the genetic, biochemistry and biology of the Met receptor, with a special emphasis on the role of this oncogene in human cancers. After a long standing career he is now acknowledged as a leader in the field.
He identified the tyrosine kinase receptor encoded by the Met oncogene (Nature. 1989; 339:155-6.) and discovered that Hepatocyte Growth Factor (HGF) is the cognate ligand (Oncogene. 1991; 6:501-4.)
He identified and elucidated the functions of three tyrosine kinase receptors, encoded by genes structurally and functionally related to Met : Ron, (EMBO J. 1994; 13:3524-32), Plexins (Cell. 1999; 99:71-80) and Ror ( Cancer Res. 2011; 71:3132-41).
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