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个人简介
Our lab focuses on the molecular nature of interactions between microbial pathogens and the host, using the intracellular bacterial pathogen Shigella. Shigella utilizes a highly sophisticated mechanism (“injectosomes” or type III secretion) to induce its uptake into the cytoplasm of host intestinal epithelial cells. Once in the cytoplasm, it actively recruits host cytoskeletal proteins to form an “actin tail” at one end of the bacterium, a process that generates force sufficient to propel it through the cytoplasm and that leads to spread into adjacent cells. Through these mechanisms, Shigella causes dysentery and diarrhea. A major focus of the research in our laboratory is the molecular mechanisms by which bacterial proteins trigger host pathways to mediate these processes. Our approaches include both genome-wide screening and targeted investigations.
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论文共 168 篇作者统计合作学者相似作者
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Dong Sun Oh,Eunha Kim, Guangqing Lu,Rachelly Normand,Lydia L Shook,Amanda Lyall, Olyvia Jasset,Stepan Demidkin, Emily Gilbert,Joon Kim,Babatunde Akinwunmi,Jessica Tantivit,
medRxiv : the preprint server for health sciences (2024)
Christopher L Schaich,Daniel E. Leisman,Marcia B. Goldberg, Micheal R. Filbin,Ashish K. Khanna,Mark C. Chappell
Peptidespp.171201-171201, (2024)
May Y Liew,Josh I Mathews,Amy Li, Rohan Singh, Salvador A Jaramillo,Zoe F Weiss,Kathryn Bowman,Pierre O Ankomah,Fadi Ghantous,Gregory D Lewis,Isabel Neuringer,Natasha Bitar,
Long H. Nguyen,Daniel Okin,David A. Drew,Vincent M. Battista,Sirus J. Jesudasen,Thomas M. Kuntz,Amrisha Bhosle,Kelsey N. Thompson,Trenton Reinicke,Chun-Han Lo, Jacqueline E. Woo, Alexander Caraballo,
Research squareno. 1 (2023): 1-14
bioRxivno. 85 (2023): eabo4767-eabo4767
Thomas E. Wood, Kathleen A. Westervelt, Jessica M. Yoon, Heather D. Eshleman,Roie Levy,Henry Burnes,Daniel J. Slade,Cammie F. Lesser,Marcia B. Goldberg
bioRxiv (2022)
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