His current research focuses on the brain specific immune functions during health and disease (autoimmune and neurodegenerative CNS disorders) and the fate of microglia in the brain. His group investigates the role of type I interferons such as IFN-alpha/beta for autoimmune inflammation (Prinz et al. Immunity 2008; Dann et al. Nat Neurosci 2011). Furthermore, the origin and function if microglia are of special interest for his research team (Goldmann et al. Nat Neurosci, 2013, Kierdorf et al. Nat Neurosci, 2013, Mildner et al. Nat Neurosci 2007, Prinz et al. Nat Neurosci 2011).