She has a long track record of single-institution, multi-institution and cooperative group clinical and translational research in acute leukemia and myelodysplastic and myeloproliferative neoplasms. In the cooperative group setting, she served as principal investigator of a phase 3 clinical trial of multidrug resistance modulation and immune modulation in previously untreated older acute myeloid leukemia patients (Cancer and Leukemia Group B [CALGB] 9720) and of immunophenotyping (CALGB 8361) and drug resistance (CALGB 9760) correlative science protocols. She is a longstanding member of the CALGB/Alliance for Clinical Trials in Oncology Leukemia and Leukemia Correlative Sciences Core Committees and a member of the Stand Up to Cancer Epigenetics Dream Team. Her laboratory works on mechanisms of drug resistance in acute myeloid leukemia and approaches to overcoming drug resistance and has been funded by the National Cancer Institute, the Leukemia and Lymphoma Society Translational Research Program and the Department of Veterans Affairs. Current resrach focuses on signal transduction pathways in acute myeloid leukemia with fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) and preclinical development of novel therapeutic approaches to acute myeloid leukemia with this common and prognostically unfavorable molecular abnormality. Finally, Dr. Baer has a long track record of mentoring students, residents, postdoctoral fellows and junior faculty.