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The main goals of our studies are to determine the mechanism of secretion and to characterize the T2S machinery and its secreted substrates so that we may identify novel ways to manipulate the secretion process for preventative, therapeutic and biotechnological use. For our studies we use two different model systems: Vibrio cholerae, the causative agent of cholera, which is a life-threatening diarrheal disease endemic to many developing countries, and Acinetobacter baumannii, an opportunistic pathogen known for its persistence in hospital settings and multidrug resistance. We focus on three main areas of research. We perform structure-function analysis of the T2SS, which is comprised of 13-15 different proteins. We run proteomic screens to identify proteins that are specifically secreted via the T2SS during virulence-inducing conditions as well as during environmental growth conditions and determine their functions. In addition, we perform high throughput screening of chemical libraries to identify small molecule inhibitors of the T2SS. This basic-translational research will generate new tools to be used to study the mechanism of secretion. They will also be exploited for development of alternatives to antibiotics to combat multi-drug resistant gram-negative pathogens.
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MBIO (2024)
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#Papers: 78
#Citation: 5568
H-Index: 40
G-Index: 74
Sociability: 5
Diversity: 0
Activity: 0
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