Mariel Vazquez
教授
Topological Molecular Biology Lab
University of California, Davis;Department of Microbiology and Molecular Genetics, College of Biological Sciences, University of California, Davis;Department of Mathematics, University of California, Davis;Center for the Advancement of Multicultural Perspectives on Science, University of California, Davis
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基本信息
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个人简介
I am a mathematical biologist who specializes in the applications of topological methods and computational tools to the study of DNA packing, DNA-protein interactions, and DNA rearrangements.
My research lies at the interface of molecular biology, mathematics, computer science and polymer physics. I specialize in the application of topological tools and discrete methods to study DNA, RNA and their interactions with proteins. My work is currently focused on the following lines of inquiry: (1) DNA Topology: the packing of chromosomes in human cells and viral capsids, and the mechanism of site-specific recombinases and topoisomerases as it relates to knotting and interlinking of DNA; (2) Evolution and dynamics of coronaviruses: we use bioinformatics, biophysical models, and topological data analysis to study viral evolution, with an emphasis on identifying complex chromosomal rearrangements; (3) Structure and formation of R-loops: using a combination of experimental and quantitative methods to study the formation and the 3-dimensional structure of R-loops and other triple helices.
My research lies at the interface of molecular biology, mathematics, computer science and polymer physics. I specialize in the application of topological tools and discrete methods to study DNA, RNA and their interactions with proteins. My work is currently focused on the following lines of inquiry: (1) DNA Topology: the packing of chromosomes in human cells and viral capsids, and the mechanism of site-specific recombinases and topoisomerases as it relates to knotting and interlinking of DNA; (2) Evolution and dynamics of coronaviruses: we use bioinformatics, biophysical models, and topological data analysis to study viral evolution, with an emphasis on identifying complex chromosomal rearrangements; (3) Structure and formation of R-loops: using a combination of experimental and quantitative methods to study the formation and the 3-dimensional structure of R-loops and other triple helices.
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biorxiv(2024)
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Muhammad Zaki Jawaid,Avinash Baidya, Sofia Jakovcevic, Jacob Lusk,Rustin Mahboubi-Ardakani, Nathan Solomon, Gina Gonzalez,Javier Arsuaga,Mariel Vazquez,Richard L Davis,Daniel L Cox
biorxiv(2022)
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciencesno. 2266 (2022)
Association for Women in Mathematics SeriesUsing Mathematics to Understand Biological Complexitypp.35-54, (2020)
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