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My laboratory is interested in the study of mobile element related genetic variation. The Alu family of mobile elements comprise approximately 10% of primate genomes and are responsible for a number of different genetic disorders (see our reviews on mobile elements Callinan and Batzer 2006; Cordaux and Batzer, 2009: Konkel and Batzer, 2010, Konkel et al., 2010). These elements are one type of L1 element dependent retrotransposon that is specific to the Primate order. A third composite retrotransposon termed SVA is restricted to hominids and also dependent on L1 elements for mobilization (Wang et al., 2005). Collectively these retrotransposons make up a significant proportion of primate genomes both in terms of copy number and overall mass. Mobile elements play a significant role in the generation of genomic diversity through a variety of processes such as insertional mutagenesis (reviewed in Deininger and Batzer 1999; Batzer and Deininger 2002; Cordaux and Batzer 2009; Konkel and Batzer 2010), transduction (Xing et al., 2006), recombination (Sen et al., 2006) and double strand break repair (Sen et al., 2007).
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Genesno. 7 (2023): 1436-1436
NATURE GENETICSno. 11 (2023): 1953-1963
Scienceno. 6648 (2023): 928-+
Natureno. 7924 (2022): E36-E36
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