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My lab studies individuals with epilepsy, focussing on one broad question: why do epileptic seizures start? In collaboration with mathematicians and engineers, we construct models of the human brain using a range of imaging and neurophysiological techniques, such as functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), electroencephalography (EEG), simultaneous EEG-fMRI and simultaneous transcranial magnetic stimulation (TMS)-EEG. We aim to understand the underlying mechanisms of seizure onset in terms of such models, comparing healthy people with people who have epilepsy. We also examine how antiepileptic drugs alter brain networks. In addition, we are investigating the long timescale mechanisms of epilepsy, through longterm monitoring of physiological parameters in people with epilepsy, using wearable and implantable sensors. We will use these data to understand why seizures occur at particular times and to forecast seizure onset in real-time.
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biorxiv(2024)
EPILEPSY & BEHAVIOR (2024): 109609-109609
Epilepsia (2024)
Bianca De Aveiro,Alice Winsor, Jessica Davies,Timothy R. Nicholson,Deb K. Pal,Mark P. Richardson,Susannah Pick
Epilepsy & Behavior (2024): 109671-109671
BMJ openno. 10 (2023): e075043-e075043
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Epilepsiano. 6 (2023): 1627-1639
Samia Elkommos, David Martin-Lopez,Akihiro Koreki,Claire Jolliffe, Rohan Kandasamy,Marco Mula,Hugo D Critchley,Mark J Edwards,Sarah Garfinkel,Mark P Richardson,Mahinda Yogarajah
Journal of neurology, neurosurgery, and psychiatryno. 9 (2023): 769-775
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EBioMedicine (2023): 104656
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