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个人简介
Dr. Stipanuk's professional career focused on the study of amino acid metabolism, particularly the metabolism of the sulfur-containing amino acid cysteine. Her work has contributed to an understanding of the intermediary pathways of cysteine metabolism in mammalian cells and of the role of various tissues in cysteine metabolism, including glutathione synthesis and taurine production, within the whole body. The Stipanuk laboratory played a major role in elucidating the physiological function, regulation, structure, and protein coenzyme formation of cysteine dioxygenase, an iron-dependent enzyme that catalyzes the first step in the cysteinesulfinate-dependent pathway of cysteine catabolism. Cysteine dioxygenase plays a crucial role in regulating cysteine levels, in promoting taurine biosynthesis, and in restricting the metabolism of cysteine through the intermediate hydrogen sulfide, preventing sulfide toxicity and facilitating hydrogen sulfide signaling. The regulation of cysteine dioxygenase abundance and activity state occurs specifically in response to cysteine levels. The Stipanuk laboratory was also interested in elucidating the mechanism(s) by which the concentrations of other amino acids are sensed by cells and how cells respond to changes in amino acid availability.
研究兴趣
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J Krijt,J Sokolová,J Šilhavý,P Mlejnek, J Kubovčiak,F Liška,H Malínská, M Hüttl,I Marková, M Křížková,M H Stipanuk, T Křížek,
mag(2015)
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