基本信息
浏览量:106
职业迁徙
个人简介
Dr. Kreek is well known for her pioneering work in the development of methadone maintenance therapy for heroin addiction in the 1960s, a therapy that has become common practice throughout the world. She also was one of the first to document that drugs of abuse significantly alter expression of specific genes in specific brain tissues and alter normal perceptions of reward and dysphoria.Dr. Kreek investigates the biological basis of addictive diseases as well as existing and novel treatments for these conditions. Her lab also researches the medical complications of drug abuse, such as hepatitis C and AIDS. This clinical and lab-based experimental approach led her lab to discover in 1983 to 1984 that the second most common risk group for HIV-1/AIDS is parenteral drug users.
Dr. Kreek’s research focuses on the endogenous opioid system, which modulates stress and pain, and the roles that specific opioid peptides and their receptors play in normal and abnormal circumstances. Heroin and morphine, which mimic endogenous peptides, as well as cocaine and alcohol activate these opiate receptors, directly or indirectly. Dr. Kreek and her colleagues examine receptor and peptide function in animals that are given or are allowed to self-administer a drug of abuse in chronic or acute doses to study how this exposure impacts the brain’s neurochemistry, neurobiology and circuitry and how to identify potential treatments. The lab also studies epigenetic, physiologic and behavioral effects of drug administration on the endogenous opioid system and related signaling networks. The scientists use microdialysis in rats and mice to conduct dynamic studies of neurotransmitter release and peptide processing in the brain.
研究兴趣
论文共 504 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Elsevier eBookspp.793-809, (2023)
引用0浏览0引用
0
0
Psychopharmacologyno. 2 (2023): 1-19
Journal of Substance Abuse and Alcoholismno. 1 (2022): 1-8
引用0浏览0引用
0
0
Brian Reed,Michael Miller,Mayako Michino,Eduardo R Butelman,Ariel Ben-Ezra, Philip Pikus,Michelle Morochnik, Yuli Kim,Amy Ripka, Joseph Vacca,Mary Jeanne Kreek
Alexandra Dolgetta,Megan Johnson, Kate Fruitman, Luke Siegel,Yan Zhou,Bruce S. McEwen,Mary Jeanne Kreek,Teresa A. Milner
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn