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We employ electrophysiological and molecular techniques to examine the excitability of cortical neurons in rats and mice. Our work focuses on the interplay of inhibitory and excitatory influences, especially as they relate to the genesis of synchronicity in neuronal networks. These processes are fundamental for understanding the mechanisms underlying the generation of seizures in epileptic patients and for developing new anti-epileptic drugs. We are also stutying a mouse model of Fragile X syndrome to identify the alterations in inhibition that occur in a specific brain structure, the subiculum. This aspect might represent a fundamental mechanism in the pathophysiogenesis of this form of mental retardation
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Journal of neurophysiologyno. 5 (2023): 1218-1223
medrxiv(2023)
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
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Nathaniel L. Gould, Gila R. Scherer,Silvia Carvalho,Khriesto Shurrush,Haneen Kayyal,Efrat Edry,Alina Elkobi,Orit David, Maria Foqara,Darshit Thakar, Tommaso Pavesi,Vijendra Sharma,
Mehdi Hooshmandi, Vijendra Sharma,Carolina Thorn Perez,Rapita Sood, Konstanze Krimbacher,Calvin Wong,Kevin C. Lister,Alba Urena Guzman,Trevor D. Bartley,Cecilia Rocha,Gilles Maussion,Emma Nadler,
Neurobiology of disease (2023): 106065-106065
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