基本信息
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Career Trajectory
Bio
My long term career objective has been to provide molecular targets, develop tools and characterize models to encourage greater pharmaceutical investment in disease-modifying therapeutics aimed at neuroprotection (‘precision medicine’). I have long had an interest in dementia, from my PhD dissertation was on ‘The genetics of age-associated cognitive dysfunction in Down syndrome’, including the role of APOE, to linkage analysis implicating increased alpha-synuclein gene dosage as the cause of Lewy body parkinsonism-dementia, to comparative high-throughput sequencing in families and populations to identify the genetic contribution to neurodegenerative trait components. I have used genetic insights to better understand genotype-phenotype correlations in man and in mouse models, with cre-loxP methods and brain slice biochemistry and physiology. In recent years I built and directed the Centre for Applied Neurogenetics and Translational Neuroscience at the University of British Columbia, and founded Neurocode Labs Inc., the only company in Canada that is clinically-accredited in medical genetics to return results from whole exome sequencing, primarily in the context of pediatric seizure disorders. As part of both endeavors, integrating genetic information, bioinformatics and web-development, my team created NeuroSeq (www.neuroseq.ca), a genome browser to enable sharing and global collaboration between neurologists and academic researchers. This proposal is a community-based effort focused on brain health and neuroprotection that aims to understand what it will take to deliver genetic information to the public. We aim to lower the risk of cognitive decline and dementia, in an underserved and socioeconomically disadvantaged sample from the population of Florida, in a meaningful and ethically-responsible fashion. It is a pilot application to improve population health, methodologically simplistic but nonetheless challenging in that it aims to modify individual behavior to lower the overall risk and incidence of Alzheimer’s disease.
Research Interests
Papers共 617 篇Author StatisticsCo-AuthorSimilar Experts
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Manuela M. X. Tan,Michael A. Lawton,Miriam I. Pollard,Emmeline Brown,Raquel Real,Alejandro Martinez Carrasco,Samir Bekadar,Edwin Jabbari,Regina H. Reynolds,Hirotaka Iwaki,Cornelis Blauwendraat,Sofia Kanavou,Leon Hubbard,Naveed Malek,Katherine A. Grosset,Nin Bajaj,Roger A. Barker,David J. Burn,Catherine Bresner,Thomas Foltynie,Nicholas W. Wood,Caroline H. Williams-Gray,Ole A. Andreassen,Mathias Toft,Alexis Elbaz,Fanny Artaud,Alexis Brice,Jean-Christophe Corvol,Jan Aasly,Matthew J. Farrer,Michael A. Nalls,Andrew B. Singleton,Nigel M. Williams,Yoav Ben-Shlomo,John Hardy,Michele T. M. Hu,Donald G. Grosset,Maryam Shoai,Lasse Pihlstrom,Huw R. Morris
NPJ Parkinson's diseaseno. 1 (2024)
A. Gopinath,A. Ramirez-Zamora,S. Franks,T. Riaz,A. Smith, G. Dizon, L. Hornstein,J. Follett, C. Swartz, J. Bravo, E.L. Kugelmann,M. Farrer, M.S. Okun,H. Khoshbouei
medrxiv(2024)
The Lancet Neurologyno. 10 (2024): 963-964
Genesno. 7 (2024): 878
Cloe Domenighetti,Pierre-Emmanuel Sugier,Ashwin Ashok Kumar Sreelatha,Claudia Schulte,Sandeep Grover,Berta Portugal,Pei-Chen Lee,Patrick May, Dheeraj Bobbili, Milena Radivojkov Blagojevic,Peter Lichtner,Andrew B. Singleton,Dena Hernandez,Connor Edsall,George D. Mellick, Alexander A. Zimprich, Walter Pirker,Ekaterina A. Rogaeva,Anthony E. Lang,Sulev Koks,Pille Taba,Suzanne Lesage,Alexis Brice, Jean-Christophe Corvol,Marie-Christine Chartier-Harlin,Eugenie Mutez,Kathrin Brockmann, Angela B. Deutschlander, Georgios M. Hadjigeorgiou, Efthimios Dardiotis,Leonidas Stefanis,Athina Maria Simitsi, Enza Maria Valente,Simona Petrucci,Letizia Straniero,Anna L. Zecchinelli,Gianni Pezzoli,Laura Brighina,Carlo Ferrarese,Grazia Annesi,Andrea Quattrone,Monica Gagliardi,Hirotaka Matsuo,Akiyoshi Nakayama,Nobutaka Hattori,Kenya Nishioka, Sun Ju Chung, Yun Joong Kim,Pierre Kolber, Bart P. C. Van De Warrenburg,Bastiaan R. Bloem, Mathias Toft, Lasse Pihlstrm, Leonor Correia Guedes,Joaquim J. Ferreira, Soraya Bardien,Jonathan Carr, Eduardo Tolosa,Mario Ezquerra, Pau Pastor,Monica Diez-Fairen,Karin Wirdefeldt,Nancy L. Pedersen,Caroline Ran, Andrea C. Belin,Andreas Puschmann,Clara Hellberg,Carl E. Clarke, Karen E. Morrison, Manuela M. Tan,Dimitri Krainc,Lena F. Burbulla,Matthew Farrer,Rejko Kruger,Thomas Gasser,Manu Sharma, Alexis Elbaz
NEUROLOGYno. 3 (2024)
Emil K Gustavsson,Jordan Follett,Joanne Trinh,Sandeep K Barodia,Raquel Real,Zhiyong Liu,Melissa Grant-Peters,Jesse D Fox,Silke Appel-Cresswell,A Jon Stoessl,Alex Rajput,Ali H Rajput,Roland Auer, Russel Tilney,Marc Sturm,Tobias B Haack,Suzanne Lesage,Christelle Tesson,Alexis Brice,Carles Vilariño-Güell,Mina Ryten,Matthew S Goldberg,Andrew B West,Michele T Hu,Huw R Morris,Manu Sharma,Ziv Gan-Or,Bedia Samanci,Pawel Lis, Teresa Tocino,Rim Amouri,Samia Ben Sassi,Faycel Hentati,Global Parkinson’s Genetics Program (GP),Francesca Tonelli,Dario R Alessi,Matthew J Farrer
medrxiv(2024)
bioRxiv : the preprint server for biology (2024)
Adithya Gopinath,Adolfo Ramirez-Zamora,Stephen Franks,Tabish Riaz,Aidan Smith, Glen Dizon, Lauryn Hornstein,Jordan Follett,Camille Swartz, Jonathan Bravo, E. Lee Kugelmann,Matthew Farrer,Michael S. Okun,Habibeh Khoshbouei
Journal of Parkinson's disease/Journal of Parkinson's disease (Online)no. 4 (2024): 883-888
A. Gopinath,A. Ramirez-Zamora, S. Franks, T. Riaz, A. Smith, G. Dizon, L. Hornstein, J. Follett, C. Swartz, J. Bravo, E.L. Kugelmann,M. Farrer, M.S. Okun,H. Khoshbouei
medrxiv(2024)
Cloé Domenighetti,Pierre-Emmanuel Sugier,Ashwin Ashok Kumar Sreelatha,Claudia Schulte,Sandeep Grover,Berta Portugal,Pei-Chen Lee,Patrick May, Dheeraj Bobbili, Milena Radivojkov Blagojevic,Peter Lichtner,Andrew B. Singleton,Dena Hernandez,Connor Edsall,George D. Mellick, Alexander A. Zimprich, Walter Pirker,Ekaterina A. Rogaeva,Anthony E. Lang,Sulev Koks, Pille Taba,Suzanne Lesage,Alexis Brice, Jean-Christophe Corvol,Marie-Christine Chartier-Harlin,Eugenie Mutez,Kathrin Brockmann, Angela B. Deutschlander, Georgios M. Hadjigeorgiou, Efthimios Dardiotis,Leonidas Stefanis,Athina Maria Simitsi, Enza Maria Valente,Simona Petrucci,Letizia Straniero,Anna L. Zecchinelli,Gianni Pezzoli,Laura Brighina,Carlo Ferrarese,Grazia Annesi,Andrea Quattrone,Monica Gagliardi,Hirotaka Matsuo,Akiyoshi Nakayama,Nobutaka Hattori,Kenya Nishioka, Sun Ju Chung, Yun Joong Kim,Pierre Kolber, Bart P.C. Van De Warrenburg,Bastiaan R. Bloem, Mathias Toft, Lasse Pihlstrøm, Leonor Correia Guedes,Joaquim J. Ferreira, Soraya Bardien,Jonathan Carr,Eduardo Tolosa,Mario Ezquerra, Pau Pastor,Monica Diez-Fairen,Karin Wirdefeldt,Nancy L. Pedersen,Caroline Ran, Andrea C. Belin,Andreas Puschmann,Clara Hellberg,Carl E. Clarke, Karen E. Morrison, Manuela M. Tan,Dimitri Krainc,Lena F. Burbulla,Matthew Farrer,Rejko Kruger,Thomas Gasser,Manu Sharma, Alexis Elbaz
Neurologyno. 3 (2024)
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Author Statistics
#Papers: 616
#Citation: 46269
H-Index: 97
G-Index: 204
Sociability: 8
Diversity: 0
Activity: 2
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