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Professor Bouchard led a research laboratory that studied the developmental genetics and disease of the urogenital system. His team dissected how fundamental mechanisms controlling tissue and organ development can also be a driving force in cancer. He explored fascinating parallels using the urogenital model that also led him to discover the genetic and molecular basis of several inherited diseases.
Professor Bouchard discovered a gene network that controls stem cell fate decisions during the normal development of the prostate gland. He showed that genetic changes associated with prostate cancer perturb this network, causing the prostate stem cell population to expand, while therapies targeting this expansion can prevent prostate cancer progression in pre-clinical models. Some of his most recent work, published in the journal ELife, paves the way for new prostate cancer therapies designed to correct imbalances in cellular populations.
Professor Bouchard discovered a gene network that controls stem cell fate decisions during the normal development of the prostate gland. He showed that genetic changes associated with prostate cancer perturb this network, causing the prostate stem cell population to expand, while therapies targeting this expansion can prevent prostate cancer progression in pre-clinical models. Some of his most recent work, published in the journal ELife, paves the way for new prostate cancer therapies designed to correct imbalances in cellular populations.
研究兴趣
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Rhythm Sharma, Rita Kalot, Yossef Levin,Sima Babayeva, Nadezda Kachurina, Chen-Feng Chung,Karen J Liu,Maxime Bouchard,Elena Torban
Development (Cambridge, England)no. 6 (2024)
Sophie Viala, Charlotte Hadjadj, Vandana Nathan,Marie-Christine Guiot,Luke McCaffrey,Katie Cockburn,Maxime Bouchard
biorxiv(2023)
You Chi Tang,Khoren Ponsin,Adda-Lee Graham-Paquin, Magdalena Schindler,Carole Luthold, Viviane Tran,Jean-François Côté,François Bordeleau,Anmar Khadra,Maxime Bouchard
SSRN Electronic Journal (2021)
Oraly Sanchez-Ferras,Alain Pacis, Maria Sotiropoulou, Yuhong Zhang,Yu Chang Wang,Mathieu Bourgey,Guillaume Bourque,Jiannis Ragoussis,Maxime Bouchard
Dervla M Connaughton,Rufeng Dai, Danielle J Owen,Jonathan Marquez,Nina Mann, Adda L Graham-Paquin,Makiko Nakayama,Etienne Coyaud,Estelle M N Laurent,Jonathan R St-Germain,Lot Snijders Blok,Arianna Vino,
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