基本信息
浏览量:10
职业迁徙
个人简介
My main interest is to study biology at the level of its macromolecular machines and to gain a quantitative biophysical understanding of how these machines drive important cell biological processes. Since new tools enable new biology, I also develop advanced microscopy methods that aim to overcome the limitations of current methods and help us visualize the macromolecular machineries of the cell in action with high spatiotemporal resolution. Specifically, I am interested in the molecular machinery involved in two fundamental biological processes: transport machinery that drives intracellular trafficking of vesicles and transcriptional machinery that drives gene expression. At the heart of and common to both biological problems is the interaction of multiple proteins with each other and with other proteins to form functional macromolecular nanoscopic complexes. The spatial and temporal organization of these interactions is tightly regulated and the failure to form these macromolecular complexes in the right place and at the right time can have catastrophic consequences. Indeed, protein copy number, protein clustering and protein mobility are all crucial parameters in intracellular transport and transcription; and failure to properly regulate them can lead to the difference between healthy function and disease.
研究兴趣
论文共 138 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Marcus A. Woodworth,Melike Lakadamyali
CURRENT OPINION IN GENETICS & DEVELOPMENT (2024): 102154-102154
Current Opinion in Biomedical Engineering (2024): 100528
biorxiv(2024)
Golbarg M Roozbahani, Patricia Colosi,Attila Oravecz,Elena M Sorokina,Wolfgang Pfeifer, Siamak Shokri, Yin Wei, Pascal Didier,Marcello DeLuca,Gaurav Arya,László Tora,Melike Lakadamyali,
bioRxiv : the preprint server for biology (2024)
CURRENT OPINION IN CELL BIOLOGY (2024): 102319-102319
ANNUAL REVIEW OF BIOPHYSICSno. 1 (2023): 139-160
引用1浏览0WOS引用
1
0
bioRxiv : the preprint server for biology (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn