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NIH supported trial conducted in 22 clinical centers in the United States. OHTS was the first trial to demonstrate definitively that treatment of elevated intraocular pressure (IOP) delays or prevents the onset of glaucomatous damage. OHTS identified risk factors for developing primary open-angle glaucoma (POAG) including older age, higher IOP and larger cup/disc ratio. OHTS was the first study to identify central corneal thickness (CCT) as an independent risk factor for the development of POAG. OHTS determined that delaying treatment of ocular hypertension for several years’ results in only a small increase in the incidence of open-angle glaucoma in low-risk patients. In contrast, delaying treatment in high-risk patients substantially increases the incidence of open-angle glaucoma. We are now working to improve the prediction model by considering other potential risk factors such as axial length, perfusion pressure and optic disc size. We are also investigating genetic factors that control quantitative traits of the eye that may be linked to glaucoma including corneal thickness and intraocular pressure. The papers listed below summarize the published outcomes of OHTS.
研究兴趣
论文共 251 篇作者统计合作学者相似作者
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Rishabh Singh, Yan Zhao,John H. Fingert,Mae O. Gordon,Michael A. Kass, Yuyang Luo,Ayellet V. Segre,Janey L. Wiggs,Tobias Elze,Nazlee Zebardast
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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OPHTHALMOLOGY GLAUCOMAno. 6 (2023): 592-598
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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Ophthalmology Scienceno. 4 (2022): 100209
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