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He and his group have recently identified novel death pathways of brain cells after stroke. After the onset of a stroke, brain cells undergo self destruction, a form of programmed cell death. This suicidal process is programmed by genetic alterations. They have identified proteins and genes responsible for the promotion of this form of cell death. With this knowledge, they may be able to intervene to inhibit this suicidal process of cell death. They have also found that after a stroke secondary events contribute to the growth of the dead tissue. A major contributing factor to this secondary injury is the influx of white blood cells into the region of damage. They have identified the signaling molecules that target these cells to the site of injury and have blocked the function of these molecules. Their data indicate that using this therapeutic approach the amount of injured brain tissue is decreased by a factor of two, and that they can significantly reduce damage from stroke. Prof. Chopp and his group have also developed novel imaging methods using magnetic resonance imaging (MRI) that permit the non invasive evaluation of the health status of brain tissue. These techniques allow them to identify whether brain cells are simply affected and compromised by the stoke, are in the process of dying or are already dead. This imaging modality may have an important impact on the treatment of stroke patients and will likely improve the management of these patients.
研究兴趣
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Liang Chen,Ye Xiong,Michael Chopp,Haiyan Pang, Marty Emanuele,Zheng Gang Zhang,Asim Mahmood,Yanlu Zhang
NEUROCHEMISTRY INTERNATIONAL (2024): 105659-105659
Tong Cheng, Anthony. L Petraglia,Zhang Li,Meenakshisundaram Thiyagarajan,Zhihui Zhong,Zhenhua Wu, Dong Liu,Sanjay. B Maggirwar,Rashid Deane,José. A Fernández, Barbra LaRue,John. H Griffin,
Nature Medicinepp.1-1, (2024)
NEURAL REGENERATION RESEARCHno. 1 (2024): 49-54
Frontiers in cellular neuroscience (2024): 1376601-1376601
Edward D. Boyd,Li Zhang,Guangliang Ding,Lian Li,Mei Lu,Qingjiang Li, Rui Huang,Jasleen Kaur,Jiani Hu,Michael Chopp,Zhenggang Zhang,Quan Jiang
BIOMEDICINESno. 2 (2024): 401
Frontiers in Neurology (2023): 1282736
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Frontiers in aging neuroscience (2023): 1180913
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ADDICTION BIOLOGYno. 12 (2023): e13353-e13353
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