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个人简介
Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. We employ a variety of experimental systems for our studies ranging from molecular biology to transgenic and knockout mice. Our current interests are:
1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia.
2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer.
3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models.
1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia.
2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer.
3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models.
研究兴趣
论文共 237 篇作者统计合作学者相似作者
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JOURNAL OF CLINICAL INVESTIGATIONno. 1 (2024)
Gaia Gentile,Teresa Poggio,Antonella Catalano, Minna Voutilainen,Mari Lahnalampi, Marta Andrade-Martinez,Tobias Ma,Roman Sankowski, Lina Goncharenko,Stefan Tholen,Kyuho Han,David W Morgens,
Blood advances (2024)
Gaia Gentile,Teresa Poggio,Antonella Catalano, Minna Voutilainen,Mari Lahnalampi, Marta Andrade-Martinez,Tobias Ma,Roman Sankowski, Lina Goncharenko,Stefan Tholen,Kyuho Han,David W. Morgens,
Blood Advances (2024)
Blood Advancesno. 11 (2023): 2504-2519
Jesús Duque-Afonso,Chiou-Hong Lin,Kyuho Han,David W. Morgens,Edwin E. Jeng,Ziming Weng, Johan Jeong, Stephen Hon Kit Wong, Li Zhu,Michael C. Wei,Hee-Don Chae,Martin Schrappe,
crossref(2023)
Li Zhu,Qin Li, Stephen H.K. Wong, Min Huang,Brianna J. Klein,Jinfeng Shen, Larissa Ikenouye,Masayuki Onishi,Dominik Schneidawind,Corina Buechele,Loren Hansen,Jesús Duque-Afonso,
crossref(2023)
Gaia Gentile,Teresa Poggio,Antonella Catalano, Minna Voutilainen,Marta Andrade-Martinez,Tobias Ma,Roman Sankowski, Lina Goncarenko,Stefan Tholen,Kyuho Han,David Morgens,Marco Prinz,
Patricia K. Grüninger,Franziska Uhl,Heike Herzog,Gaia Gentile,Marta Andrade-Martinez, Tobias Schmidt,Kyuho Han,David W. Morgens,Michael C. Bassik,Michael L. Cleary,Oliver Gorka,Robert Zeiser,
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