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The focus of our research is in the development of stable isotope and mass spectrometry based approaches to improve our understanding of biology on a molecular, cellular, and whole organism level. Presently, individuals in the laboratory are working on technology for 1) automating biochemical sample preparation methods for the analysis of protein mixtures; 2) developing in vivo stable isotope methods for studying protein metabolism; 3) increasing the dynamic range of liquid chromatography-mass spectrometry for the analysis of peptides; and 4) developing computational tools for the automated conversion of mass spectrometry data into biologically meaningful results. These technologies are presently being demonstrated in the model organisms C. elegans and S. cerevisiae. Although our current research interests are presently in model systems, our long-term goal is have technologies robust enough to handle the automated high-throughput characterization of human clinical samples.
研究兴趣
论文共 401 篇作者统计合作学者相似作者
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Annie Moradian, Elisha Goonatilleke, Tai-Tu Lin, Maya Hatten-Beck,Michelle Emrick,Athena A Schepmoes,Thomas L Fillmore,Michael J MacCoss,Salvatore Sechi,Kimia Sobhani,Randie Little,Kuanysh Kabytaev,
Clinical Chemistry (2024)
Michael C Saul, Elizabeth M Litkowski,Niran Hadad,Amy R Dunn, Stephanie M Boas, Jon A L Wilcox, Julia E Robbins,Yiyang Wu,Vivek M Philip,Gennifer E Merrihew,Jea Park,Philip L De Jager,
bioRxiv : the preprint server for biology (2024)
Annie Moradian, Elisha Goonatilleke, Tai-Tu Lin, Maya Hatten-Beck,Michelle Emrick,Athena A Schepmoes,Thomas L Fillmore,Michael J MacCoss,Salvatore Sechi,Kimia Sobhani,Randie Little,Kuanysh Kabytaev,
Clinical chemistry (2024)
Kristine A Tsantilas,Gennifer E Merrihew, Julia E Robbins,Richard S Johnson,Jea Park,Deanna L Plubell,Eric Huang,Michael Riffle,Vagisha Sharma,Brendan X MacLean,Josh Eckels,Michael B Bereman,
bioRxiv : the preprint server for biology (2024)
Amanda C Baldassi, Julia Robbins, Leticia R Moretto,Gennifer E Merrihew,Michael J MacCoss,Tiago S Balbuena
Plant Stress (2024): 100438
Christine C. Wu,Kristine A. Tsantilas,Jea Park,Deanna Plubell, Justin A. Sanders,Previn Naicker, Ireshyn Govender,Sindisiwe Buthelezi,Stoyan Stoychev,Justin Jordaan,Gennifer Merrihew,Eric Huang,
biorxiv(2024)
bioRxiv : the preprint server for biology (2024)
Rachel L Lombardi,John S Ramsey, Jaclyn E Mahoney,Michael J MacCoss,Michelle L Heck,Carolyn M Slupsky
Journal of proteome research (2024)
Kate T. Carroll,Emma Federico, Patrick Fillingham,Dominic A. Nistal,Guilherme Barros,R. Michael Meyer, Alexandra Gonzalez,Malia McAvoy, Jade Keen, Do Hyeong Lim, Andrew Hoofnagle, Grant O'Keefe,
Neurosurgeryno. Supplement_1 (2024): 55-55
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