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个人简介
In my research, I am collaborating with my colleagues to assess a class of drugs called histone deacetylase inhibitors as anticancer agents. These novel drugs work against cancer by turning off an enzyme the cancers need to grow. I have studied the mechanisms by which cancers metastasize (spread), and I am working with other investigators to study the role of angiogenesis — the development of blood vessels tumors need — in this process. Since metastasis is what ultimately causes patients to succumb to cancer, learning how to halt this process will be enormously beneficial.
I also lead clinical trials, such as one assessing radioimmunotherapy for desmoplastic small round cell tumors. My work supports the banking of tumor tissue, particularly for neuroblastoma and sarcoma — the study of which can benefit future patients with cancer. I also teach and mentor surgical fellows and residents.
Nationally, I serve as Chairperson of the Surgical Committee of the Children’s Oncology Group. I am a member and past chairman of the Pediatric Surgical Association Cancer Committee. I have received the Willet F. Whitmore Award for Clinical Excellence from Memorial Sloan Kettering and am a fellow of the Royal College of Surgeons in Edinburgh. I hold the Joseph H. Burchenal Chair in Pediatrics, which is named for an esteemed pioneer in the treatment of cancer in children. The National Cancer Institute also gave me an award for my work on the Pediatric Physician Data Query (PDQ) information summaries, which provide up-to-date cancer information for healthcare professionals and parents/patients.
研究兴趣
论文共 84 篇作者统计合作学者相似作者
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Courtney J. Harris, Irene Helenowski,Andrew J. Murphy, Sara A. Mansfield,Michael P. LaQuaglia, Todd E. Heaton, Michele Cavalli,Joseph T. Murphy,Erika Newman,Richard E. Overmen, Tanvi T. Kartal,Jo Cooke-Barber,
Annals of Surgery (2020)
James A. Saltsman, Enrico Danzer,William J. Hammond, Daniel Rhee, Simon Berhe, Julie Monteagudo, Anita P. Price, Todd E. Heaton, David R. Jones,Michael P. LaQuaglia
Annals of Surgeryno. 2 (2019)
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