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Stress and pain-induced behavior is controlled by specific neurotransmitters and their signaling partners in the central and peripheral nervous systems. Many of these signals are conveyed through activation of neuropeptide and monoamine receptor systems. These receptors are seven transmembrane spanning G-protein coupled receptors (GPCR, also called 7 transmembrane receptors) and they engage a variety of signaling cascades following neurotransmitter release and receptor binding. To expand our knowledge of the inner workings of the brain and to identify treatments for psychiatric diseases, the Bruchas laboratory aims to dissect how GPCR systems function in the contexts of stress, depression, addiction, and pain. We strive for a greater understanding of these receptors in real time, within intact systems, and biologically relevant models of behavior. We utilize pharmacological, optogenetic, genetic, viral, imaging, behavioral, and cutting-edge engineering approaches to uncover the specific role of GPCRs and their endogenous transmitters within in vivo neural circuits that modulate affective behavior.
Stress and pain-induced behavior is controlled by specific neurotransmitters and their signaling partners in the central and peripheral nervous systems. Many of these signals are conveyed through activation of neuropeptide and monoamine receptor systems. These receptors are seven transmembrane spanning G-protein coupled receptors (GPCR, also called 7 transmembrane receptors) and they engage a variety of signaling cascades following neurotransmitter release and receptor binding. To expand our knowledge of the inner workings of the brain and to identify treatments for psychiatric diseases, the Bruchas laboratory aims to dissect how GPCR systems function in the contexts of stress, depression, addiction, and pain. We strive for a greater understanding of these receptors in real time, within intact systems, and biologically relevant models of behavior. We utilize pharmacological, optogenetic, genetic, viral, imaging, behavioral, and cutting-edge engineering approaches to uncover the specific role of GPCRs and their endogenous transmitters within in vivo neural circuits that modulate affective behavior.
研究兴趣
论文共 233 篇作者统计合作学者相似作者
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British Journal of Pharmacology (2024)
Anthony English, Fleur Uittenbogaard,Alexa Torrens,Dennis Sarroza, Anna Veronica Elizabeth Slaven,Daniele Piomelli,Michael R. Bruchas,Nephi Stella,Benjamin Bruce Land
ELIFE (2024)
Madelyn M. Hjort,Raajaram Gowrishankar, Lucy Tian,Adam Gordon-Fennell, Vijay M. K. Namboodiri,Michael R. Bruchas,Garret D. Stuber
Neurophotonicsno. 03 (2024)
Christian E Pedersen,Raajaram Gowrishankar,Sean C Piantadosi,Daniel C Castro, Madelyn M Hjort, Zhe C Zhou, Shane A Kan, Patick J Murphy,Patrick R O'Neill,Michael Bruchas
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Abraham Escobedo, Salli-Ann Holloway,Megan Votoupal, Aaron L Cone, Hannah E Skelton,Alex Legaria,Imeh Ndiokho, Tasheia Floyd,Alexxai V Kravitz,Michael R Bruchas,Aaron J Norris
biorxiv(2024)
David Marcus, Emma Seth, Sabrina Hwang, Rachel Oomen,Anthony English,Christian Pedersen,Avery Hunker,Azra Suko,Yulong Li,Nephi Stella,Larry Zweifel,Michael Bruchas
NEUROPSYCHOPHARMACOLOGY (2023): 484-484
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NEUROPSYCHOPHARMACOLOGY (2023): 422-422
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Sean C Piantadosi,Zhe Charles Zhou, Carina Pizzano,Christian E Pedersen, Tammy K Nguyen, Sarah Thai,Garret D Stuber,Michael R Bruchas
Neuronno. 4 (2023): 593-610.e5
Flora D'Oliveira da Silva, Cathaline Robert, Emma Lardant, Carina Pizzano,Michael R Bruchas,Bruno P Guiard, Frédéric Chauveau,Lionel Moulédous
Molecular psychiatry (2023)
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