基本信息
浏览量:0
职业迁徙
个人简介
Research in my laboratory focuses on understanding the molecular mechanisms involved in regulation of drug transport proteins particularly as it pertains to pathophysiological changes in drug disposition. The influence of disease and endogenous mediators on the gene expression and functionality of transport proteins is examined using a combination of in vivo, in vitro, in situ and molecular biology techniques. The combination of these methods allows us to assess clinical relevance as well as to ascertain the underlying cellular and molecular mechanisms involved.
Another research direction of the laboratory has focused on examining methods to suppress the the ABC drug efflux transporters in tumor cells, a leading cause of multidrug resistance and drug failure in cancer. This has resulted in collaborative research programs with Dr. Christine Allen and Dr. Ray Reilly with the primary goal to develop novel therapeutics and treatment strategies in the treatment of ovarian and breast cancer.
Another research direction of the laboratory has focused on examining methods to suppress the the ABC drug efflux transporters in tumor cells, a leading cause of multidrug resistance and drug failure in cancer. This has resulted in collaborative research programs with Dr. Christine Allen and Dr. Ray Reilly with the primary goal to develop novel therapeutics and treatment strategies in the treatment of ovarian and breast cancer.
研究兴趣
论文共 157 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
PHARMACEUTICSno. 7 (2023): 1857-1857
REPRODUCTIVE SCIENCES (2023): 87A-88A
引用0浏览0引用
0
0
Clinical pharmacology and therapeuticsno. 3 (2023): 634-642
Drug metabolism and disposition: the biological fate of chemicalsno. 10 (2023): 1308-1315
引用1浏览0WOS引用
1
0
DRUG METABOLISM AND DISPOSITIONno. 10 (2023): 1308-1315
引用0浏览0引用
0
0
CLINICAL PHARMACOLOGY & THERAPEUTICSno. 3 (2022): 461-484
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn