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个人简介
The Zhou Lab's research interests are directed at better understanding of the biology of epigenetic control of gene transcription of the human genome to attain both the underlying basic principles and rational design of novel chemical compounds that modulate gene expression. It has broad implications in human biology and disease, ranging from cell development, to stem cell self-renewal and differentiation, and re-programming to human cancer and inflammation, as well as neurodegenerative disorders. The Zhou Lab was the first to discover the bromodomain as the lysine-acetylated histone binding domain (‘chromatin reader’) in gene transcription (Nature 1999), and demonstrate druggability and therapeutic potential of modulating bromodomain/acetyl-lysine binding in gene expression to treat a wide array of human diseases including cancer and inflammation (JACS 2005; Cancer Cell 2014, 2015; PNAS 2017; 2018). This concept has had transformative impact in epigenetic drug discovery in the pharmaceutical industry (NSMB 2019).
研究兴趣
论文共 277 篇作者统计合作学者相似作者
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Dustin C. Becht,Akinori Kanai, Soumi Biswas, Mohamed Halawa, Lei Zeng,Khan L. Cox,Michael G. Poirier,Ming-Ming Zhou,Xiaobing Shi,Akihiko Yokoyama,Tatiana G. Kutateladze
iScienceno. 4 (2024): 109367-109367
Ka Lung Cheung, Li Zhao,Rajal Sharma, Anurupa Abhijit Ghosh, Michael Appiah, Yifei Sun,Anbalagan Jaganathan,Yuan Hu,Alannah LeJeune,Feihong Xu,Xinye Han, Xueting Wang,
Proceedings of the National Academy of Sciences of the United States of Americano. 18 (2024): e2312111121-e2312111121
Li Zhao, Yiqi Wang,Anbalagan Jaganathan, Yifei Sun,Ning Ma,Ning Li,Xinye Han,Xueying Sun,Huanfa Yi,Shibo Fu,Fangbin Han, Xue Li,
Molecular cellno. 13 (2023): 2206-2221.e11
Current Opinion in Chemical Biology (2023): 102323-102323
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Donna A. Santillan, Catherine M. Theisler, Amanda S. Ryan,Relja Popovic, Tara Stuart,Ming-Ming Zhou,Serhan Alkan,Nancy J. Zeleznik-Le
crossref(2023)
Nature communicationsno. 1 (2023): 378-16
crossref(2023)
Journal of molecular biologyno. 7 (2023): 168376-168376
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