Areas of Expertise: Medicinal chemistry, organic synthesis, anticancer drug development, drug design, antibody-drug conjugates, tumour hypoxia. RESEARCH INTERESTS - Development of antibody-drug conjugates (ADCs), with particular emphasis on the design of payloads and drug-linkers producing an enhanced therapeutic window - The design, synthesis, and properties of hypoxia-selective prodrugs for use as anticancer agents - DNA alkylating agents, in particular minor groove alkylating agents (cyclopropylindolines, pyrrolobenzodiazepines) - New nitroimidazoles for the detection of hypoxic cells