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The overall goal of the Trebak laboratory is to investigate the activation mechanisms of ion channels and their contribution to pathophysiology using animal models of disease. The lab’s work is centered on the role of STIM/Orai Ca2+ channels and Transient Receptor Potential (TRP) cation channels in the processes of survival, proliferation and migration in cancer and pathological remodeling of airways and vessels. The Trebak lab’s in vivo studies are complemented by the use of a variety of molecular, biochemical, biophysical and imaging techniques to gain mechanistic insights into regulation of these ion channels by various signaling pathways under native conditions of expression and the effector proteins and transcription factors that are activated downstream of these calcium entry channels.
Professor with a demonstrated history in cutting edge research, grant funding, training and education, consulting and academic administration. Skilled in biochemistry, ion channel biophysics, microscopy, molecular biology, cell biology, and animal models of human disease. Strong collaborative portfolio with academic and industry partners.
研究兴趣
论文共 242 篇作者统计合作学者相似作者
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Journal of theoretical biology (2024): 111740-111740
Olivier Romito, Aude Lemettre,Aurelie Chantome, Ophelie Champion, Noemie Couty,Lobna Ouldamer,Nadine Hempel,Mohamed Trebak,Caroline Goupille,Marie Potier-Cartereau
MOLECULAR ONCOLOGY (2024)
Journal of Biological Chemistryno. 4 (2024): 107145-107145
Olivier Romito, Aude Lemettre,Aurélie Chantôme, Ophélie Champion, Noémie Couty,Lobna Ouldamer,Nadine Hempel,Mohamed Trebak,Caroline Goupille,Marie Potier‐Cartereau
crossref(2024)
bioRxiv : the preprint server for biology (2024)
Frontiers in Systems Biology (2024)
FUNCTIONno. 2 (2024): zqae007-zqae007
ELIFE (2023)
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