基本信息
浏览量:25
职业迁徙
个人简介
Areas of Interest
We are interested in exploring how cells regulate their survival and death. How does a cell decide whether to survive and cope, or trigger apoptosis in response to different stimuli? If the apoptotic pathway is activated, what is its mechanism and how is it regulated?
Cell death by apoptosis occurs extensively during development and is seen in many pathological conditions such as after stroke or in neurodegenerative diseases. In contrast, the inability of cells to undergo apoptosis is a fundamental hallmark of cancers. Therefore, understanding the mechanisms by which different cells regulate apoptosis has significant therapeutic implications.
We are particularly interested in identifying the unique ways in which different cells control apoptosis. For example, apoptosis is highly restricted in postmitotic cells such as neurons- which is beneficial for their long-term survival. In contrast, embryonic stem cells are primed to undergo rapid apoptosis in response to DNA damage- an ability that permits for the rapid elimination of damaged cells during embryonic development.
Thus, we focus on studying how cell survival and death is regulated in neurons, stem cells and cancer cells in cell culture as well as in mouse models of neurodegeneration, cancer, and aging.
研究兴趣
论文共 93 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Alexandria J. Shumway,Michael T. Shanahan,Emilie Hollville,Kevin Chen, Caroline Beasley, Jonathan W. Villanueva, Sara Albert,Grace Lian, Moises R. Cure,Matthew Schaner,Lee-Ching Zhu,Surekha Bantumilli,
medRxiv : the preprint server for health sciences (2023)
Cell death and differentiationno. 5 (2023): 1097-1154
Richa Basundra,Sahil Kapoor,Emilie Hollville,Nazanin Kiapour, Adriana Beltran Lopez, Nicole Marie Melchiorre,Mohanish Deshmukh
Vijay Swahari,Ayumi Nakamura,Emilie Hollville,Hume Stroud,Jeremy M Simon,Travis S Ptacek, Matthew V Beck, Cornelius Flowers,Jiami Guo, Charlotte Plestant,Jie Liang,C Lisa Kurtz,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn